Genetic polymorphisms of CYP24A1 gene and cancer susceptibility: a meta-analysis including 40640 subjects

Wang, Yubin; Wang, Ruiwen; Yuan, Shaofei; Liu, Xiaotang

doi:10.1186/s12957-023-03156-w

World Journal of Surgical Oncology

Table 1 The main characteristics of the included studies

From: Genetic polymorphisms of CYP24A1 gene and cancer susceptibility: a meta-analysis including 40640 subjects

First author	Year	Country	Ethnicity	Cancer type	Sample size		Case			Controls			HWE (control)
First author	Year	Country	Ethnicity	Cancer type	Case	Control	AA	AB	BB	AA	AB	BB	HWE (control)
rs2296241
Holt a	2009	USA	Caucasian	Prostate cancer	692	705	166	356	170	151	371	183	0.147
Holt b	2009	USA	African	Prostate cancer	112	66	25	50	37	12	39	15	0.134
Wu	2017	China	Asian	Lung cancer	426	445	119	230	77	114	227	104	0.662
Holick	2007	UK	Caucasian	Prostate cancer	571	539	134	285	152	107	275	157	0.497
McCullough	2007	USA	Caucasian	Breast cancer	494	490	99	254	141	98	253	139	0.377
Penna-Martinez PTC	2012	Germany	Caucasian	Thyroid carcinoma	205	302	47	101	57	62	151	89	0.889
Penna-Martinez FTC	2012	Germany	Caucasian	Thyroid carcinoma	48	302	17	22	9	62	151	89	0.889
Yang	2017	China	Asian	ESCC	569	556	116	263	190	113	292	151	0.192
Anderson	2011	Canada	Caucasian	Breast cancer	1556	1630	330	777	449	371	791	468	0.294
Oh	2009	Korea	Asian	Prostate cancer	272	173	64(A%)	36(B%)		55.8(A%)	44.2(B%)
Beuten	2011	USA	Caucasian	Prostate cancer	609	348	48.4(A%)	51.6(B%)		47(A%)	53(B%)
Beuten	2011	USA	Caucasian	Prostate cancer	195	514	55.4(A%)	44.6(B%)		55.9(A%)	44.1(B%)
Beuten	2011	USA	African	Prostate cancer	82	109	54.9(A%)	45.1(B%)		49.7(A%)	50.3(B%)
rs4809957
Anderson	2013	Canada	Caucasian	Pancreas cancer	627	1189	362	232	33	749	377	63	0.088
Zhuo	2018	China	Asian	Lung cancer	322	384	124	152	46	143	185	56	0.759
Gong	2017	China	Asian	Colorectal cancer	524	595	206	260	58	230	295	70	0.093
Wei	2019	China	Asian	Breast cancer	378	402	134	180	64	162	197	43	0.144
rs2762939
Holt a	2009	USA	Caucasian	Prostate cancer	702	715	380	272	50	376	294	45	0.324
Holt b	2009	USA	African	Prostate cancer	114	67	29	48	37	13	32	22	0.824
Wu	2017	China	Asian	Lung cancer	426	445	160	192	74	156	220	69	0.553
Holick	2007	UK	Caucasian	Prostate cancer	568	539	319	212	37	300	196	43	0.173
Reimers	2015	USA	Caucasian	Breast cancer	921	970	514	348	59	560	353	57	0.889
rs4809960
Holick	2007	UK	Caucasian	Prostate cancer	586	544	329	230	27	323	184	37	0.129
Holt a	2009	USA	Caucasian	Prostate cancer	697	693	432	220	45	387	260	46	0.794
Holt b	2009	USA	African	Prostate cancer	112	63	93	18	1	46	17	0	0.216
Reimers	2015	USA	Caucasian	Breast cancer	948	989	522	342	84	512	395	82	0.637
Clendenen	2015	Sweden	Caucasian	Breast cancer	733	1433	479	218	36	861	496	76	0.679
Sadeghi	2020	Iran	Caucasian	Colorectal cancer	220	243	119	95	6	105	119	19	0.062
Yi	2019	China	Asian	Colorectal cancer	787	800	415	311	61	468	290	42	0.736
rs6068816
Holick	2007	UK	Caucasian	Prostate cancer	583	544	454	118	11	443	93	8	0.227
Holt a	2009	USA	Caucasian	Prostate Cancer	699	712	558	135	6	580	127	5	0.493
Reimers	2015	USA	Caucasian	Breast cancer	948	990	778	164	6	784	189	17	0.158
Clendenen	2015	Sweden	Caucasian	Breast cancer	733	1432	590	136	7	1149	264	19	0.389
Yi	2019	China	Asian	Colorectal cancer	787	800	342	354	91	362	348	90	0.645
Qu	2019	China	Asian	Lung cancer	345	351	160	155	30	131	178	42	0.116

HWE Hardy–Weinberg equilibrium, ESCC Esophageal squamous cell carcinoma, a Caucasian population, b African population, A wild type allele, B Mutated type allele

Back to article page

ISSN: 1477-7819

Contact us

General enquiries: journalsubmissions@springernature.com