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Table 2 Univariate and Multivariate analyses of prognostic factors in patients with PMOC presenting for curative-intent CRS

From: Prognostic value of peritoneal scar-like tissue in patients with peritoneal metastases of ovarian origin presenting for curative-intent cytoreductive surgery

Variables

DFS

OS

Univariate

Mutlivariate

Univariate

Mutlivariate

HR (95%CI)

p

HR (95%CI)

p

HR (95%CI)

p

HR (95%CI)

p

Age (cont)

1.01 (0.99–1.02)

0.35

  

1.01 (0.99–1.03)

0.19

  

BMI (cont)

1.00 (0.97–1.03)

0.91

  

1.01 (0.97–1.05)

0.76

  

CA125 pre-Tx > 321 u/ml

1.27 (0.91–1.77)

0.16

  

1.25 (0.85–1.85)

0.25

  

CA 125 post-Tx > 38 u/ml

1.11 (0.80–1.55)

0.51

  

1.39 (0.94–2.07)

0.09

1.13 (0.74–1.74)

0.57

NAC

0.88 (0.62–1.25)

0.47

  

0.93 (0.62–1.39)

0.73

  

FIGO

III vs II

2.62 (1.15-

0.02

1.81 (0.78-

0.17

3.73 (1.17-

0.025

2.52 (0.76-

0.13

IVa vs II

5.97)

3.01 (1.21–7.44)

0.17

4.24)

1.88 (0.73–4.82)

0.19

11.8)

5.35 (1.56–18.3)

0.008

8.31)

3.43 (0.96–12.27)

0.05

PCI > 8

1.97 (1.41–2.76)

 < 0.001

1.78 (1.25–2.53)

0.001

2.16 (1.45–3.24)

 < 0.001

1.87 (1.20–2.91)

0.005

Primary tumor histology:

Serous vs Other or mixed

0.76 (0.44–1.31)

0.32

  

0.92 (0.50–1.69)

0.79

  

Degree of differentiation:

Moderate vs well

2.04 (0.96–4.32)

0.06

2.04 (0.96–4.32)

0.06

2.51 (1.11–5.68)

0.027

2.19 (0.95–5.04)

0.06

Poor vs well

2.20 (1.15–4.22)

0.01

2.03 (1.06–3.89)

0.03

1.84 (0.89–3.83)

0.099

1.53 (0.73–2.21)

0.26

Positive LN status

0.96 (0.67–1.38)

0.86

  

0.99 (0.65–1.50)

0.97

  

HIPEC

0.83 (0.47–1.46)

0.52

  

0.86 (0.44–1.65)

0.65

  

CD complication:

CD 0-I-II vs CD III-IV

1.14 (0.71–1.83)

0.59

  

1.19 (0.69–2.03)

0.52

  

Positive PST

1.35 (0.92–1.99)

0.12

1.15 (0.77–1.70)

0.49

1.01 (0.62–1.61)

0.97

  
  1. BMI Body mass index, PCI pEritoneal carcinomatosis index, NAC Neoadjuvant chemotherapy, pre-cytoreductive surgery, LN Lymph nodes, HIPEC: Hyperthermic intraperitoneal chemotherapy, CRS Cytoreductive surgery, CD Clavien-Dindo, PST Peritoneal scar tissue