Table 1 Patients’ pre-, intra-, and post-operative demographic, clinical and histopathological characteristics
Variables | N = 193 (%) | Absence of PST N = 114 (59.1%)c | Presence of PST N = 79 (40.9%)c | p | Negative PST N = 39 (49.3%)c | Positive PST N = 40 (50.7%)c | p |
|---|---|---|---|---|---|---|---|
Mean Age (± SD) in years | 61 (± 12) | 58.8 (± 11.9) | 63.7 (± 11.7) | 0.005 | 62.5 (12) | 64.8 (11.4) | 0.39 |
Median BMI [IQR] kg/m2 | 23.8 [6] | 23.8 [7] | 23.8 [6] | 0.91 | 24 [5] | 23.6 [7] | 0.91 |
ASA score | |||||||
I | 11 (5.7) | 7 (6.1) | 4 (5.1) | 0.37 | 2 (5.2) | 2 (5) | 0.91 |
II | 138 (71.5) | 85 (74.6) | 53 (67.1) | 27 (69.2) | 26 (65) | ||
III | 44 (22.8) | 22 (19.3) | 22 (27.8) | 10 (25.6) | 12 (30) | ||
IV | - | - | - | - | - | ||
Median CA125 pre-NAC [IQR] u/ml | 321 [820] | 367 [877.5] | 257 [803] | 0.26 | 522 [1118] | 210 [256.7] | 0.58 |
Median CA125 post-NAC [IQR] u/ml | 38 [139.5] | 42.5 [210.7] | 30 [87] | 0.59 | 31 [142] | 29 [60] | 0.91 |
NAC | |||||||
Yes | 133 (69) | 76 (66.7) | 57 (72.2) | 0.41 | 29 (74.4) | 28 (70) | 0.66 |
No | 60 (31) | 38 (33.3) | 22 (27.8) | 10 (25.6) | 12 (30) | ||
Median number of NAC cycles | 3 [4] | 3 [4] | 3 [4] | 0.94 | 3 [4] | 3 [4] | 0.75 |
FIGO stagea | |||||||
II | 12 (6.2) | 9 (7.9) | 3 (3.8) | 0.48 | 3 (7.7) | 0 | 0.20 |
III | 153 (79.3) | 88 (77.2) | 65 (82.3) | 31 (79.5) | 34 (85) | ||
IVab | 28 (14.5) | 17 (14.9) | 11 (13.9) | 5 (12.8) | 6 (15) | ||
Primary tumor histology | |||||||
Serous | 169 (87.5) | 100 (87.7) | 69 (87.3) | 0.93 | 31 (79.5) | 38 (95) | 0.038 |
Other or mixed | 24 (12.5) | 14 (12.3) | 10 (12.7) | 8 (20.5) | 2 (5) | ||
Degree of differentiation | |||||||
Well | 27 (14) | 15 (13.2) | 12 (15.2) | 0.66 | 10 (25.7) | 2 (5) | 0.028 |
Moderate | 27 (14) | 18 (15.8) | 9 (11.4) | 5 (12.8) | 4 (10) | ||
Poor | 139 (72) | 81 (71) | 58 (73.4) | 24 (61.5) | 34 (85) | ||
Lymph nodes status | |||||||
Positive | 53 (27.6) | 83 (72.8) | 56 (71.8) | 0.88 | 13 (34.2) | 9 (22.5) | 0.25 |
Negative | 139 (72.4) | 31 (27.2) | 22 (28.2) | 25 (65.8) | 31 (77.5) | ||
Median PCI [IQR] | 8 [12] | 9 [12] | 7 [11] | 0.38 | 5 [10] | 9 [13] | 0.03 |
HIPEC | |||||||
No | 170 (88.1) | 107 (93.9) | 63 (79.7) | 0.003 | 30 (76.9) | 33 (82.5) | 0.53 |
Yes | 23 (11.9) | 7 (6.1) | 16 (20.3) | 9 (23.1) | 7 (17.5) | ||
Median intraoperative blood loss [IQR] in cc | 1300 [1993] | 1000 [1800] | 1600 [2025] | 0.043 | 1825 (2075) | 1500 [1900] | 0.39 |
Median CRS time [IQR] in min | 326 [275] | 283 [264] | 390 [208] | 0.001 | 406 [206] | 380 [216] | 0.12 |
CD complications | 191 | 113 | 78 | 0.21 | 38 | 40 | 0.65 |
No complications | 86 (45) | 56 (49.5) | 30 (38.5) | 17 (44.7) | 13 (32.5) | ||
CD-I | 31 (16.2) | 19 (16.8) | 12 (15.4) | 5 (13.2) | 7 (17.5) | ||
CD-II | 49 (25.7) | 23 (20.4) | 26 (33.3) | 13 (34.2) | 13 (32.5) | ||
CD-IIIA | 7 (3.7) | 3 (2.7) | 4 (5.1) | 2 (5.3) | 2 (5) | ||
CD-IIIB | 7 (3.7) | 4 (3.5) | 3 (3.8) | 1 (2.6) | 2 (5) | ||
CD-IV | 10 (5.2) | 8 (7.1) | 2 (2.6) | 0 | 2 (5) | ||
CD-V | 1 (0.5) | 0 | 1 (1.3) | 0 | 1 (2.5) | ||
Median number of scar [IQR] | - | - | 2 [2] | - | 2 [2] | 2 [2] | 0.94 |
Median DFS (95% CI) in months | 22 (18.8–25.2) | 22 (16.8–27.1) | 22 (16.8–27.1) | 0.88 | 29 (20.1–37.9) | 17 (14.9–19) | 0.05 |
Median OS (95% CI) in months | 66 (58.9–73.1) | 64 (49.8–78.1) | 66 (56.3–75.6) | 0.56 | 68 (43.2–92.8) | 64 (48.4–79.6) | 0.63 |