Table 2 Multivariate analysis of OS and CSS of iPCN patients who underwent curative resection using the Cox proportional hazards model
Variables | OS | P value | CSS | P value |
|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
Age | ||||
< 56 | 1 [reference] | 1 [reference] | ||
56–75 | 1.330 (1.069–1.653) | 0.010 | 1.193 (0.945–1.506) | 0.137 |
> 75 | 2.050 (1.599–2.627) | < 0.001 | 1.650 (1.259–2.163) | < 0.001 |
Sex | ||||
Female | 1 [reference] | 1 [reference] | ||
Male | 1.004 (0.860–1.173) | 0.958 | 0.910 (0.767–1.080) | 0.282 |
Race | ||||
White | 1 [reference] | 1 [reference] | ||
Black | 1.029 (0.788–1.345) | 0.832 | 0.949 (0.699–1.290) | 0.740 |
Others | 0.639 (0.482–0.848) | 0.002 | 0.653 (0.476–0.895) | 0.008 |
Histologic type | ||||
iIPMN | 1 [reference] | 1 [reference] | ||
iMCN | 0.836 (0.649–1.077) | 0.165 | 0.901 (0.682–1.191) | 0.464 |
iSPN | 0.034 (0.005–0.244) | < 0.001 | NA | NA |
iSCN | 0.628 (0.086–4.562) | 0.645 | 0.751 (0.103–5.479) | 0.777 |
Pathological grade | ||||
I | 1 [reference] | 1 [reference] | ||
II | 1.521 (1.254–1.844) | < 0.001 | 1.563 (1.254–1.947) | < 0.001 |
III–IV | 2.114 (1.684–2.653) | < 0.001 | 2.131 (1.655–2.743) | < 0.001 |
Year of diagnosis | ||||
2000–2008 | 1 [reference] | 1 [reference] | ||
2009–2017 | 0.827 (0.701–0.976) | < 0.025 | 0.785 (0.656–0.941) | 0.009 |
Primary site | ||||
Head | 1 [reference] | 1 [reference] | ||
Body and tail | 1.105 (0.911–1.340) | 0.312 | 1.045 (0.842–1.298) | 0.690 |
Others | 0.924 (0.684–1.247) | 0.603 | 0.952 (0.685–1.323) | 0.769 |
Chemotherapy | ||||
Yes | 1 [reference] | 1 [reference] | ||
No/unknown | 1.218 (1.011–1.469) | 0.038 | 1.045 (0.851–1.283) | 0.674 |
Radiotherapy | ||||
Yes | 1 [reference] | 1 [reference] | ||
No/unknown | 1.075 (0.889–1.301) | 0.455 | 1.147 (0.934–1.408) | 0.190 |
Regional nodes examined | ||||
0–7 | 1 [reference] | 1 [reference] | ||
8–14 | 0.829 (0.686–1.003) | 0.053 | 0.789 (0.639–0.973) | 0.027 |
> 14 | 0.667 (0.548–0.813) | < 0.001 | 0.603 (0.484–0.751) | < 0.001 |
T stage | ||||
T1 | 1 [reference] | 1 [reference] | ||
T2 | 1.388 (1.103–1.747) | 0.005 | 1.458 (1.125–1.890) | 0.004 |
T3 | 1.309 (1.037–1.651) | 0.023 | 1.266 (0.970–1.653) | 0.083 |
T4 | 3.176 (2.219–4.547) | < 0.001 | 3.166 (2.139–4.688) | < 0.001 |
N stage | ||||
N0 | 1 [reference] | 1 [reference] | ||
N1 | 2.081 (1.733–2.500) | < 0.001 | 2.303 (1.881–2.821) | < 0.001 |
N2 | 2.822 (2.240–3.554) | < 0.001 | 3.212 (2.500–4.129) | < 0.001 |
M stage | ||||
M0 | 1 [reference] | 1 [reference] | ||
M1 | 1.624 (1.194–2.208) | 0.002 | 1.749 (1.263–2.422) | < 0.001 |