The optimal surgery timing after stenting in colorectal cancer patients with malignant obstruction: additionally compared with emergency surgery

Na, Ji Eun; Kim, Eun Ran; Kim, Ji Eun; Hong, Sung Noh; Kim, Young Ho; Chang, Dong Kyung

doi:10.1186/s12957-023-03130-6

Table 1 Clinic-pathologic characteristics among emergency surgery, self-expandable metal stents, and stratified time intervals of the stent

From: The optimal surgery timing after stenting in colorectal cancer patients with malignant obstruction: additionally compared with emergency surgery

	ES (n = 133)	SEMS (n = 220)	P^a	< 11 (n = 68)	P^b	11–17 (n = 97)	P^c	> 17 (n = 55)	P^d	P^*	P**	P***
Age, years†	60 (51, 71)	67 (57, 76)	< 0.001	67 (55, 76)	0.025	65 (57, 74)	0.003	69 (57, 78)	< 0.001	0.10	0.48	0.15
Sex			0.36		0.81		0.49		0.23	0.99	0.99	0.38
Male	72 (54.1)	130 (59.1)		38 (55.9)		57 (58.8)		35 (63.6)
Female	61 (45.9)	90 (40.9)		30 (44.1)		40 (41.2)		20 (36.4)
BMI	23 (21, 25)	22 (20, 25)	0.08	22 (20, 24)	0.16	22 (21, 24)	0.19	22 (19, 25)	0.17	0.95	0.95	0.99
ASA III	8 (6.0)	22 (10.0)	0.19	4 (5.9)	0.99	7 (7.2)	0.72	11 (20.0)	0.004	0.99	0.07	0.017
Preoperative CEA†	2.7 (1.6, 6.9)	2.8 (1.4, 5.4)	0.54	2.1 (1.2, 4.9)	0.43	3.4 (1.7, 7.3)	0.60	2.3 (1.2, 4.4)	0.55	0.034	0.09	0.63
Neoadjuvant chemotherapy	0 (0.0)	6 (2.7)	0.09	0 (0.0)	–	0 (0.0)	–	6 (10.9)	0.001	0.99	0.004	0.007
Location			< 0.001		< 0.001		< 0.001		< 0.001	0.40	0.88	0.12
Right	71 (53.4)	25 (11.4)		11 (16.2)		8 (8.2)		6 (10.9)
Left	46 (34.6)	175 (79.6)		54 (79.4)		80 (82.5)		41 (74.6)
Rectum	16 (12.0)	20 (9.1)		3 (4.4)		9 (9.3)		8 (14.5)
Pathologic size, cm†	5.5 (4.5, 7.0)	7.0 (6.0, 8.0)	< 0.001	7.0 (6.0, 7.8)	0.003	7.0 (6.0, 8.0)	< 0.001	7.0 (6.0, 8.0)	0.004	0.33	0.58	0.71
Undifferentiated histology	22 (16.5)	10 (4.6)	< 0.001	5 (7.4)	0.07	3 (3.1)	0.001	2 (3.6)	0.016	0.55	0.99	0.46
Lymphatic invasion, present	47 (35.9)	86 (39.1)	0.55	23 (33.8)	0.77	38 (39.2)	0.61	25 (45.5)	0.22	0.99	0.99	0.19
Venous invasion, present	23 (20.9)	35 (15.9)	0.26	4 (5.9)	0.007	22 (22.7)	0.76	9 (16.4)	0.49	0.008	0.81	0.06
Peri-neural invasion, present	37 (29.8)	133 (60.5)	< 0.001	36 (52.9)	0.002	65 (67.0)	< 0.001	32 (58.2)	< 0.001	0.15	0.59	0.56
MSI, high	14 (12.5)	10 (4.7)	0.011	3 (4.6)	0.08	2 (2.1)	0.005	5 (9.6)	0.59	0.80	0.19	0.30
T stage			< 0.001		0.003		0.015		< 0.001	0.31	0.07	0.50
T2	2 (1.5)	3 (1.4)		2 (2.9)		0 (0.0)		1 (1.8)
T3	65 (48.9)	156 (70.9)		48 (70.6)		64 (66.0)		44 (80.0)
T4	66 (49.6)	61 (27.7)		18 (26.5)		33 (34.0)		10 (18.2)
N stage			0.53		0.52		0.80		0.66	0.99	0.99	0.85
N0	56 (42.1)	106 (48.2)		34 (50.0)		45 (46.4)		27 (49.1)
N1	53 (39.9)	77 (35.0)		22 (32.4)		35 (36.1)		20 (36.4)
N2	24 (18.0)	37 (16.8)		12 (17.6)		17 (17.5)		8 (14.5)
Pathologic stage			0.27		0.29		0.52		0.38	0.99	0.99	0.92
I–II	56 (42.1)	106 (48.2)		34 (50.0)		45 (46.4)		27 (49.1)
III	77 (57.9)	114 (51.8)		34 (50.0)		52 (53.6)		28 (50.9)
Follow-up duration, month^†	64 (22, 95)	36 (14, 59)	< 0.001	46 (13, 63)	< 0.001	37 (15, 57)	< 0.001	30 (13, 44)	< 0.001	0.51	0.53	0.010

Values are expressed as n (%) unless otherwise specified
ASA American Society of Anesthesiologists, BMI body mass index, CEA Carcinoembryonic antigen, ES emergency surgery, MSI microsatellite instability, SEMS self-expendable metal stent
^†Value is median (IQR, interquartile range)
P value calculated using Student’s t test and Wilcoxon rank sum test for continuous variables or chi-square test and Fisher’s exact test for categorical variables
^a,b,c,dP value was a comparison of emergency surgery and the time interval groups with < 11 days, 11–17 days, and > 17 days, respectively
^{*, **, ***}P value was a comparison of the time interval groups with < 11 days and 11–17 days, 11–17 days, and > 17 days, and < 11 days and > 17 days, respectively. Those were compared using Tukey’s test after rank transformation and Fisher’s exact test with the Bonferroni method

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