Fig. 2

Treatment timeline and clinical response of the NRG1 fusion-positive patient with afatinib. A Timeline of the patient’s clinical treatment course. B–I Computed tomography (CT) scan of the chest in different afatinib treatment stages, CT images of lung primary tumor (B), and interlobar pleural metastasis (C) at baseline before afatinib therapy. Primary tumor and interlobar pleural metastases shrinked after 1 month (D, E), 7 months (F, G), and 14 months (H, I) of afatinib treatment. J Dynamic changes of carcinoembryonic antigen (CEA) during afatinib therapy. BEV, Bevacizumab; NVB, Navelbine; PTX, Paclitaxe