Fig. 1From: Durable response to afatinib in advanced lung adenocarcinoma harboring a novel NPTN-NRG1 fusion: a case reportIdentification and verification of a novel NPTN-NRG1 fusion. A RNA sequencing reads indicating NRG1 fusion regions were visualized by the Integrative Genomic Viewer (IGV) software. B Schematic of genomic rearrangement involving the fusion breakpoints in mRNA and protein level. C Sanger sequencing confirmed the NPTN-NRG1 fusion transcript and showed the breakpoint sequence. D The number of NRG1 EGF-like domain α or β isoform-specific read in RNA-based NGS data. E Reverse transcriptase-polymerase chain reaction (RT-PCR) confirmed the α or β transcript variants of NRG1Back to article page