Patients | Study heterogeneity | |||||||
---|---|---|---|---|---|---|---|---|
Outcomes of interest | Studies | AR | PSR | WMD/RR/HR (95% CI) | P value | I2(%) | P value | Effect model |
Long-term | ||||||||
Overall survial (OS) | 22 | 3154 | 4074 | 1.08(0.95–1.22) | 0.245 | 49.3 | 0.005 | Random |
3‐year OS | 13 | 1668 | 2878 | 0.99(0.92–1.06) | 0.728 | 55.4 | 0.008 | Random |
5‐year OS | 18 | 2760 | 3692 | 0.93(0.86–1.00) | 0.054 | 44.9 | 0.021 | Random |
Disease‐free survival (DFS) | 14 | 2260 | 3368 | 1.09(0.94–1.28) | 0.259 | 75.1 | < 0.001 | Random |
3‐year DFS | 10 | 1237 | 2581 | 0.98(0.89–1.07) | 0.66 | 0 | 0.897 | Fixed |
5‐year DFS | 14 | 2260 | 3368 | 0.88(0.73–1.07) | 0.212 | 70.1 | < 0.001 | Random |
3‐year Liver-RFS | 5 | 386 | 496 | 1.02(0.9–1.15) | 0.789 | 0 | 0.79 | Fixed |
5‐year Liver-RFS | 5 | 386 | 496 | 1.00(0.88–1.14) | 0.981 | 0 | 0.592 | Fixed |
Short‐term | ||||||||
Duration of operation (min) | 13 | 1234 | 1364 | 51.48(29.03–73.93) | < 0.001 | 98.6 | < 0.001 | Random |
Estimated blood loss (mL) | 10 | 886 | 992 | 189.92(21.39–358.45) | 0.027 | 98.6 | < 0.001 | Random |
Intraoperative blood transfusion | 12 | 1799 | 3004 | 2.24(1.54–3.26) | < 0.001 | 74 | < 0.001 | Random |
Length of hospital stay (day) | 15 | 1813 | 3011 | 1.00(0.34–1.67) | 0.003 | 66.6 | < 0.001 | Random |
Positive margin (mm) | 12 | 1244 | 1080 | 0.77(0.61–0.97) | 0.024 | 33.9 | 0.119 | Fixed |
Postoperative complications | 12 | 1880 | 3116 | 2.28(1.88–2.77) | < 0.001 | 0 | 0.639 | Fixed |
90‐day mortality | 7 | 1711 | 2826 | 3.08(1.88–5.03) | < 0.001 | 0 | 0.796 | Fixed |
Intrahepatic recurrence | 15 | 2299 | 2036 | 0.90(0.82–0.98) | 0.021 | 26.2 | 0.166 | Fixed |
Repeat hepatectomy | 14 | 2362 | 3398 | 0.64(0.55–0.76) | < 0.001 | 12.4 | 0.317 | Fixed |