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Fig. 3 | World Journal of Surgical Oncology

Fig. 3

From: TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway

Fig. 3

The AKT inhibitor LY294002 rescued the function of TRIM58 in LOVO cells. LOVO cells were transduced with TRIM58 shRNA and treated with LY294002. A Cell viability was measured using CCK-8 assay. B, C Cell cycle was measured through flow cytometry. D Protein levels of AKT, p-AKT, p21, and cyclin D1 were measured through Western blotting. ***p < 0.001 vs. shNC + Vehicle. ###p < 0.001 vs. shTRIM58 + Vehicle

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World Journal of Surgical Oncology

ISSN: 1477-7819

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