Fig. 1

TRIM58 was downregulated in colorectal cancer (CRC) tissues. A A comparison of TRIM58 expression between colon adenocarcinoma tissues and normal tissues from the Gene Expression Profiling Interactive Analysis database. B Comparison of TRIM58 expression between CRC tissues and normal tissues from the hospital cohort using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). C Comparison of TRIM58 expression between CRC tissues and normal tissues from the hospital cohort using Western blotting. D Comparison of TRIM58 expression between tumor and normal tissues from CRC tissue microarrays using immunohistochemistry (scale bar, 100 μm). E Kaplan–Meier analysis indicated that the downregulation of TRIM58 was associated with poor prognosis of patients with CRC. F, G Bioinformatics analyses indicated that TRIM58 was correlated with the genes involved in cell cycle and AKT signaling pathway in CRC. H, I qRT-PCR and western blot were used to examine the relative mRNA and protein levels of TRIM58 in FHC, SW480, HCT15, SW620, LOVO, and SW1417 cells. ***p < 0.001 vs. paracancerous tissues or FHC