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Table 1 Patient clinical characteristics

From: Dissociated response to PD-1 inhibitors combined with radiotherapy in patients with advanced metastatic solid tumors: a single-center experience

Characteristic

Total(%)

n = 93

DR

n = 22

No-DR

n = 71

P value

Age*

63±13

60±13

64±12

0.243

Sex

    

 Female

43 (46.2)

15 (68.2)

28 (39.4)

0.018

 Male

50 (53.8)

7 (31.8)

43 (60.6)

 

ECOG ps

    

1

20 (21.5)

3 (13.6)

17 (24.0)

0.566

2

52 (55.9)

14 (63.7)

38 (53.5)

 

3

21 (22.6)

5 (22.7)

16 (22.5)

 

No. of prior systemic therapies

    

 < 3

72 (77.4)

15 (68.2)

53 (74.6)

0.550

 ≥ 3

21 (22.6)

7 (31.8)

18 (25.4)

 

Metastatic organs involved

    

 < 3

68 (73.1)

16 (72.7)

56 (78.9)

0.547

 ≥ 3

25 (26.9)

6 (27.3)

15 (21.1)

 

PD-L1 status

   

0.260

 < 1

15 (16.1)

5 (22.7)

10 (14.1)

 

 ≥ 1

19 (20.4)

2 (9.1)

17 (23.9)

 

 Unknown

59 (63.5)

15 (68.2)

44 (62.0)

 

Primary cancer sites

   

 0.541

 Lung

18 (19.4)

4 (18.2)

14 (19.7)

 

 Colorectum

16 (17.2)

3 (13.7)

13 (18.3)

 

 Breast

4 (4.3)

1 (4.5)

3 (4.2)

 

 Gastro

7 (7.5)

0 (0.0)

7 (9.9)

 

 Cervix

7 (7.5)

4 (18.2)

3 (4.2)

 

 Esophagus

10 (10.8)

2 (9.1)

8 (11.3)

 

 Ovary

5 (5.4)

2 (9.1)

3 (4.2)

 

 Head and neck

6 (6.5)

1 (4.5)

5 (7.0)

 

 Liver

6 (6.5)

1 (4.5)

5 (7.0)

 

 Pancreas

6 (6.5)

1 (4.5)

5 (7.0)

 

 Others

8 (8.4)

3 (13.7)

5 (7.0)

 

No. of irradiated sites

    

 1

38 (40.9)

6 (27.3)

32 (45.1)

0.332

 2

38 (40.9)

11 (50.0)

27 (38.0)

 

 ≥ 3

17 (18.2)

5 (22.7)

12 (16.9)

 

Tumor response by lesion to lesion

    

 Uniform response

27 (29.0)

   

 Dissociated response

22 (23.7)

   

 Only stable lesions

20 (21.5)

   

 Uniform progression

24 (25.8)

   
  1. ECOG ps ECOG PS Eastern Cooperative Oncology Group Performance Status
  2. *Mean ± standard deviation