Fig. 2

Representative radiological data of patients with dissociated responses. A 67-year-old man with advanced lung adenocarcinoma. He started PD-1 inhibitors combined with radiotherapy as a fifth-line therapy. The radiation site was a metastatic lesion of the right iliac crest. After 22 weeks of treatment, his pulmonary metastasis lesions (the largest: 25 mm) reduced in size (c, d), although two new metastatic lymph nodes (the larger: 43 mm) in the mediastinum were detected on the CT scan (a, b); therefore, DR was diagnosed