Carbon nanoparticles localized clipped node dissection combined with sentinel lymph node biopsy with indocyanine green and methylene blue after neoadjuvant therapy in node positive breast cancer in China: initial results of a prospective study

Table 2 Studies that have analyzed the feasibility of marked lymph nodes and /or SLN to stage axilla after NAT

Author	Year	No. of patients^a	SLN IR (%)	Tracers for SLNs	Marked node and/or SLN IR	Matched rate of marked nodes with SLNs (%)	Methods to visualize marked nodes	FNR (%)	Median of SLN
Donker, et al [13]	2015	100	-	-	97	-	¹²⁵I seed	7 for MARI nodes	-
Caudle, et al [14]	2016	85	95.5	BD + RI OR RI	94.8	77	¹²⁵I seed	2 for TAD nodes 4.2 for clipped nodes 10.1 for SLN	2.7
Cabioglu, et al [15]	2018	98	87.8	BD + RI (N = 37) BD (N = 61)	95.6	81.4	Specimen radiographs	11.4 for all 4.7 for clipped + doubel tracing	2
Simons, et al [20]	2022	212	86.4	BD + RI	98.2	71.3	¹²⁵I seed	3.5 for RISAS nodes 17.6 for SLN 7 for MARI nodes	/
This article	2023	38	100	ICG + BD	100	76.3	carbon nanoparticles	6.25 for TAD nodes 9.38 for SLN 18.75 for clipped nodes	5

Abbreviations: FNR False-negative rate, ¹²⁵I Iodine-125, IR Identification rate, MARI Marking the axillary lymph node with radioactive iodine seeds, NAT Neoadjuvant therapy, RISAS Radioactive iodine seed localization in the axilla combined with sentinel node procedure, SLN Sentinel lymph node, TAD Targeted axillary dissection
^aThis includes all patients in whom ALND is performed with TAD

ISSN: 1477-7819