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Table 3 Univariate and multivariate Cox regression survival analysis for the prediction of OS

From: Prognostic value and model construction of preoperative inflammatory markers in patients with metastatic renal cell carcinoma

Characteristicsb

Total(N)

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P valuea

Hazard ratio (95% CI)

P valuea

Gender

198

    

Male

154

Reference

   

Female

44

1.161 (0.687–1.962)

0.577

  

Age

198

1.004 (0.986–1.022)

0.687

  

Hemoglobin

198

0.987 (0.978–0.995)

0.002

0.991 (0.981–1.001)

0.065

Postoperative medication

198

    

Absent

35

Reference

   

TK1

25

0.747 (0.365–1.530)

0.425

  

PD1

138

0.680 (0.396–1.167)

0.162

  

Tumor site

198

    

Left

120

Reference

   

Right

78

0.951 (0.607–1.490)

0.828

  

Number of metastatic sites

198

    

 < 2

151

Reference

   

 ≥ 2

47

1.123 (0.683–1.848)

0.648

  

Histology

198

    

Clear cell

176

Reference

   

Non–clear cell

22

2.235 (1.216–4.108)

0.010

1.820 (0.964–3.436)

0.065

Microvascular invasion

198

    

Present

47

Reference

   

Absent

151

0.823 (0.491–1.379)

0.459

  

Tumor size (cm)

198

    

 > 7

116

Reference

   

 ≤ 7

82

1.379 (0.891–2.133)

0.149

  

Nephrectomy

198

    

Minimally invasive

176

Reference

   

Open

22

0.321 (0.117–0.879)

0.027

0.397 (0.140–1.126)

0.082

Fuhrman grade

198

    

G1 + G2

108

Reference

   

G3 + G4

90

1.407 (0.909–2.178)

0.126

  

T stage

198

    

T1 + T2

54

Reference

   

T3 + T4

144

1.917 (1.094–3.358)

0.023

1.263 (0.702–2.271)

0.436

N stage

198

    

N0

147

Reference

   

N1

51

1.021 (0.610–1.708)

0.937

  

Tumor necrosis

198

    

Present

98

Reference

   

Absent

100

0.542 (0.348–0.844)

0.007

0.524 (0.328–0.838)

0.007

LMR

198

0.736 (0.625–0.867)

 < 0.001

0.783 (0.650–0.943)

0.010

NLR

198

1.127 (1.049–1.211)

0.001

0.948 (0.823–1.091)

0.457

ALR

198

1.007 (1.005–1.010)

 < 0.001

1.005 (1.001–1.008)

0.006

  1. The difference between groups was tested using the Chi-squared test
  2. aStatistically significant results were in bold
  3. bAbbreviations: NLR stands for neutrophil-to-lymphocyte ratio; ALR stands for aspartate aminotransferase-to-lymphocyte ratio; and LMR stands for lymphocyte-to-monocyte ratio