Evaluation of multiple biological indicators for the combined diagnosis of metastases from colorectal cancer—a retrospective study based on 1163 patients

Table 3 AUC area under the subject operating characteristics, CI confidence interval, Sen sensibility, Spe specificity, Youden index, PPV positive predictive value, NPV negative predictive value, P-values for comparisons using the DeLong test. Predictive probability of combined CRC tumor markers (P1), CRC tumor markers combined with PLR (P2), CRC tumor markers combined with NLR (P3), and CRC tumor markers combined with PLR and NLR (P4) were calculated using binary logistic regression, Ref reference

	AUC	95% CI	Cutoff	Sen	Spe	Youden index	PPV	NPV	p-value
CA50	0.648	0.608–0.687	15.20	0.447	0.814	0.261	0.416	0.832	< 0.001
CA199	0.671	0.632–0.711	16.22	0.620	0.686	0.306	0.369	0.859	< 0.001
CEA	0.695	0.658–0.731	6.400	0.654	0.682	0.336	0.379	0.869	< 0.001
PLR	0.677	0.642–0.713	139.8	0.726	0.561	0.287	0.329	0.873	< 0.001
NLR	0.690	0.654–0.726	2.735	0.677	0.629	0.306	0.353	0.866	< 0.001
P1	0.716	0.680–0.752	0.189	0.635	0.691	0.326	0.379	0.865	0.010
P2	0.749	0.715–0.782	0.175	0.767	0.603	0.370	0.364	0.897	0.0495
P3	0.752	0.719–0.785	0.208	0.568	0.795	0.363	0.451	0.861	0.146
P4	0.761	0.728–0.794	0.208	0.586	0.804	0.390	0.470	0.868	Ref

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