Table 4 Univariate and multivariate analysis of factors related to nipple or skin sensation post nipple-sparing mastectomy

Univariate analysis

Nipple sensation

Skin sensation

Total

Satisfy^a (N)

%

OR

CI

p-value

OR

CI

p-value

Age

 < 40

75

17

22.7

1

1

 ≧ 40 and < 60

329

97

29.5

1.42

0.79–2.57

0.23

0.94

0.55–1.60

0.83

 ≧ 60

56

19

33.9

1.75

0.80–3.79

0.15

1.31

0.64–2.68

0.45

Surgical methods

 C-NSM

174

63

36.2

1

1

 E-NSM

195

52

26.7

0.64

0.41–0.99

0.04

0.42

0.27–0.61

< 0.01

 R-NSM

91

18

19.8

0.43

0.23–0.79

< 0.01

0.18

0.09–0.34

< 0.01

Surgical ALN staging method

 SLNB

298

94

31.5

1

1

 SLNB + ALND

85

14

16.5

0.42

0.22–0.79

< 0.01

0.85

0.51–1.44

0.56

 ALND

31

11

35.5

1.19

0.54–2.59

0.65

2.36

1.12–4.99

0.02

Surgical wound location

 Upper outer (radial + other)

71

17

23.9

1

1

 Infra-mammary Fold

18

6

33.3

1.58

0.51–4.87

0.41

1.91

0.67–5.45

0.22

 Peri-areolar

156

60

38.5

1.98

1.05–3.74

0.03

1.53

0.86–2.71

0.14

 Single axillary or lateral chest

215

50

23.3

0.96

0.51–1.8

0.90

0.38

0.40–0.68

< 0.01

Specimen size, g

 < 180

66

24

36.4

1

1

 180–320

173

51

29.5

0.73

0.40–1.33

0.30

0.74

0.41–1.34

0.32

 320–450

93

24

25.8

0.60

0.30–1.20

0.15

0.90

0.46–1.73

0.75

 > 450

80

21

26.3

0.62

0.30–1.26

0.18

0.88

0.44–1.73

0.71

Operation time

0.99

0.99–1.00

0.33

1.00

0.99–1.00

0.86

Follow-up time (time since surgery), month

 ≦ 12 m

86

10

11.6

1

1

 > 12 m and ≦ 36 m

155

39

25.2

2.55

1.2–5.42

0.01

1.52

0.83–2.79

0.17

 > 36 m and ≦ 60 m

97

37

38.1

4.68

2.15–10.1

< 0.01

2.12

1.11–4.05

0.02

 > 60 m

122

47

38.5

4.76

2.24–10.1

< 0.01

2.45

1.32–4.53

< 0.01

Multivariate analysis

Nipple sensation (stepwise)

Skin sensation (stepwise)

Total

Satisfy (N)

%

OR

CI

p-value

OR

CI

p-value

Surgical methods

 C-NSM

174

63

36.2

1

1

 E-NSM

195

52

26.7

0.39

0.19–0.79

0.01

0.58

0.31–1.08

0.08

 R-NSM

91

18

19.8

0.23

0.09–0.6

< 0.01

0.29

.011–0.74

0.01

Surgical wound location

 Upper outer (radial + other)

71

17

23.9

1

1

 Inframammary fold

18

6

33.3

2.08

0.62–6.88

0.23

2.02

0.69–5.95

0.19

 Peri-areolar

156

60

38.5

2.84

1.4–5.73

< 0.01

1.74

0.95–3.22

0.07

 Single axillary or lateral chest

215

50

23.3

3.76

1.32–10.7

0.01

0.79

0.32–1.97

0.61

Follow-up time (time since surgery), month

 ≦ 12 m

86

10

11.6

1

1

 > 12 m and ≦ 36 m

155

39

25.2

2.77

1.28–5.98

< 0.01

1.96

1.03–3.75

0.04

 > 36 m and ≦ 60 m

97

37

38.1

5.49

2.46–12.3

< 0.01

2.72

1.35–5.48

< 0.01

 > 60 m

122

47

38.5

5.75

2.55–12.9

< 0.01

1.97

1.0–3.89

< 0.05

Multivariate Analysis

Nipple sensation (stepwise)

Skin sensation (stepwise)

Total

Satisfy (N)

%

OR

CI

p-value

OR

CI

p-value

Surgical wound location

 Upper outer (radial + other)

71

17

23.9

1

1

 Inframammary fold

18

6

33.3

1.8

0.56–5.86

0.31

1.9

0.65–5.5

0.23

 Peri-areolar

156

60

38.5

2.1

1.09–4.04

0.02

1.5

0.84–2.67

0.16

 Single axillary or lateral chest

215

50

23.3

1.2

0.58–2.32

0.65

0.4

0.19–0.67

< 0.01

Follow-up time (time since surgery), month

 ≦ 12 m

86

10

11.6

1

1

 > 12 m and ≦ 36 m

155

39

25.2

2.5

1.2–5.53

0.01

1.8

0.97–3.5

0.06

 > 36 m and ≦ 60 m

97

37

38.1

4.8

2.19–10.5

< 0.01

2.4

1.2–4.71

0.01

 > 60 m

122

47

38.5

4.2

1.97–9.32

< 0.01

1.7

0.86–3.18

0.12

Multivariate analysis

Nipple sensation (stepwise)

Skin sensation (stepwise)

Total

Satisfy (N)

%

OR

CI

p-value

OR

CI

p-value

Surgical methods

 C-NSM

174

63

36.2

1

1

 E-NSM

195

52

26.7

0.7

0.41–1.04

0.07

0.42

0.27–0.65

< 0.01

 R-NSM

91

18

19.8

0.4

0.21–0.77

< 0.01

0.16

0.08–0.32

< 0.01

Follow-up time after op, m

 ≦ 12 m

86

10

11.6

1

1

 > 12 m and ≦ 36 m

155

39

25.2

2.9

1.35–6.2

< 0.01

1.9

1.05–3.72

0.03

 > 36 m and ≦ 60 m

97

37

38.1

5.4

2.4–11.9

< 0.01

2.7

1.4–5.55

< 0.01

 > 60 m

122

47

38.5

4.5

2.1–9.64

< 0.01

2.2

1.2–4.26

0.01