Table 2 Univariate and multivariate Cox regression analysis in patients with HCC

Age at diagnosis

  ≤ 50 years

1.000 [Reference]

-

-

-

  > 50 years

1.358 [0.734, 2.512]

0.329

-

-

Gender

 Male

1.000 [Reference]

-

-

-

 Female

0.442 [0.107, 1.829]

0.260

-

-

HBsAg

 Negative

1.000 [Reference]

-

 Positive

1.097 [0.509, 2.365]

0.814

AFP

 Negative

1.000 [Reference]

-

-

-

 Positive

1.512 [0.817, 2.797]

0.188

-

-

Tumor size

  < 50 mm

1.000 [Reference]

-

-

-

  ≥ 50 mm

1.676 [0.904, 3.108]

0.101

-

-

Cirrhosis

 Negative

1.000 [Reference]

-

-

-

 Positive

1.589 [0.568, 4.446]

0.377

-

-

Grade

 Grade I and II

1.000 [Reference]

-

1.000 [Reference]

-

 Grade III

1.970 [1.063, 3.650]

0.031

1.733 [0.930, 3.228]

0.083

AJCC stage

 I

1.000 [Reference]

-

1.000 [Reference]

-

 II and III

1.861 [1.018, 3.402]

0.044

1.890 [1.020, 3.503]

0.022

RPL27A

 Low-level

1.000 [Reference]

-

1.000 [Reference]

-

 High-level

2.137 [1.131, 4.037]

0.019

2.123 [1.115, 4.046]

0.043

PD-1

 Negative

1.000 [Reference]

-

-

-

 Positive

0.689 [0.379, 1.253]

0.222

-

-