Clinical significance of matrix metalloproteinase-9 expression in papillary thyroid carcinoma: a meta-analysis

Table 1 The basic characteristics of the enrolled papers in the study

Author	Year	Country	Period	Method	Cut-off value	Sample size			Indicator	NOS score
Author	Year	Country	Period	Method	Cut-off value	High MMP-9	Low MMP-9	Total	Indicator	NOS score
Li Na [12]	2019	China	2016	IHC	Index ≥ 4	23	17	40	1	7
Wang Ni [13]	2014	China	2011–2012	IHC	Score ≥ 3	48	35	83	1, 2, 3, 4	7
Tian Wei [14]	2017	China	2013–2015	IHC	Score ≥ 3	72	16	88	2, 3, 4, 5	7
Yang Lei [15]	2014	China	2010–2011	IHC	Score ≥ 5	39	33	72	1, 2, 4	6
Meng Xianying [16]	2014	China	2007–2012	IHC	≥ 25%	61	5	66	1, 2, 3, 4, 5	8
Shi Jianhua [17]	2010	China	2002–2006	IHC	> 10%	115	42	157	1	6
Roncevic, J. [18]	2019	Serbia	2000–2015	IHC	NR	29	74	103	1, 2, 4, 5	8
Dong Yuhong [19]	2012	China	2009–2010	IHC	Score ≥ 3	115	53	168	1, 2, 4	6
Wang Zhaohui [20]	2012	China	2012–2010	IHC	> 10%	46	10	56	1, 2, 4	6
Chen Suqin [21]	2018	China	2003–2016	IHC	Score ≥ 3	164	36	200	1, 2, 3, 4	6
Huang Pei [22]	2013	China	2002–2010	IHC	NR	36	22	58	1, 4, 5	6
Liu Xincheng [23]	2020	China	2016–2017	IHC	Score ≥ 4	65	39	104	1, 2, 4, 5	8
Zhang Jie [24]	2010	China	2004–2007	IHC	Score ≥ 3	54	20	74	1	7
Liu Zhen [25]	2014	China	2010–2013	IHC	Score ≥ 3	116	48	164	1, 2, 3, 4, 5	7

Indicator: 1, LNM; 2, TNM; 3, tumour size; 4, gender; 5, age; NR, not report in literature

ISSN: 1477-7819