Table 1 Indirect comparisons of outcomes among different treatments

OS

 Donafenib

  1.79 (0.64,5.21)

HAIC

  1.4 (0.54,3.71)

0.79 (0.38,1.62)

HAIC_Sorafenib

  0.84 (0.26,2.59)

0.46 (0.18,1.15)

0.59 (0.25,1.39)

Lenvatinib

  0.89 (0.33,2.53)

0.5 (0.23,1.07)

0.64 (0.32,1.28)

1.07 (0.44,2.72)

SIRT

  1.03 (0.28,4.06)

0.58 (0.18,1.86)

0.73 (0.24,2.27)

1.25 (0.36,4.53)

1.16 (0.48,2.8)

SIRT_Sorafenib

  0.83 (0.35,1.95)

0.46 (0.25,0.83)

0.59 (0.38,0.9)

0.99 (0.48,2.12)

0.93 (0.53,1.57)

0.8 (0.28,2.2)

Sorafenib

  0.77 (0.27,2.2)

0.43 (0.22,0.82)

0.55 (0.26,1.13)

0.92 (0.38,2.23)

0.86 (0.43,1.67)

0.74 (0.24,2.2)

0.93 (0.51,1.68)

TACE

  1.7 (0.5,5.75)

0.95 (0.34,2.53)

1.21 (0.44,3.19)

2.05 (0.94,4.39)

1.92 (0.68,5)

1.65 (0.42,6.05)

2.05 (0.84,4.9)

2.2 (0.88,5.47)

TACE_Lenvatinib

  0.88 (0.31,2.51)

0.49 (0.24,0.99)

0.63 (0.3,1.3)

1.06 (0.45,2.51)

0.99 (0.47,1.97)

0.85 (0.27,2.59)

1.06 (0.58,1.93)

1.14 (0.74,1.79)

0.52 (0.22,1.23)

TACE_Sorafenib

PFS

 TACE_Lenvatinib

  0.79 (0.17, 3.94)

HAIC_Sorafenib

  0.43 (0.15, 1.21)

0.55 (0.16, 1.79)

Lenvatinib

  0.41 (0.08, 1.99)

0.52 (0.22, 1.09)

0.95 (0.26, 3.19)

HAIC

  0.38 (0.07, 1.93)

0.48 (0.18, 1.22)

0.88 (0.24, 3.16)

0.91 (0.4, 2.27)

TACE_Sorafenib

  0.32 (0.05, 1.84)

0.4 (0.12, 1.3)

0.73 (0.17, 3.06)

0.76 (0.23, 2.77)

0.84 (0.23, 3.03)

Donafenib

  0.3 (0.06, 1.46)

0.38 (0.15, 0.91)

0.68 (0.2, 2.29)

0.72 (0.3, 1.86)

0.78 (0.31, 1.99)

0.94 (0.28, 3.16)

SIRT

  0.29 (0.07, 1.23)

0.36 (0.18, 0.68)

0.66 (0.24, 1.82)

0.7 (0.35, 1.46)

0.76 (0.35, 1.67)

0.9 (0.33, 2.51)

0.96 (0.5, 1.9)

Sorafenib

  0.25 (0.05, 1.26)

0.31 (0.12, 0.77)

0.57 (0.15, 2.01)

0.6 (0.27, 1.35)

0.65 (0.36, 1.14)

0.78 (0.21, 2.72)

0.84 (0.33, 1.99)

0.86 (0.39, 1.84)

TACE

TTP

 HAIC

  0.28 (0.06, 1.19)

HAIC_Sorafenib

  0.33 (0.07, 1.52)

1.15 (0.51, 3)

SIRT

  0.24 (0.06, 0.92)

0.84 (0.51, 1.45)

0.73 (0.34, 1.43)

Sorafenib

  0.19 (0.04, 0.84)

0.68 (0.25, 1.6)

0.58 (0.23, 1.16)

0.8 (0.34, 1.58)

TACE

  0.53 (0.09, 3.16)

1.92 (0.51, 6.89)

1.65 (0.44, 5.42)

2.25 (0.66, 7.17)

2.83 (1.03, 8.5)

TACE_Lenvatinb

  0.29 (0.06, 1.31)

1.04 (0.42, 2.48)

0.9 (0.37, 1.88)

1.23 (0.58, 2.44)

1.54 (1.05, 2.51)

0.55 (0.21, 1.43)

TACE_Sorafenib

AE

 SIRT

  0.89 (0.12, 5.53)

HAIC

  0.7 (0.05, 9.97)

0.8 (0.06, 12.81)

Donafenib

  0.64 (0.11, 3.78)

0.73 (0.14, 4.35)

0.9 (0.06, 15.96)

TACE

  0.62 (0.06, 6.05)

0.7 (0.04, 14.3)

0.88 (0.03, 31.19)

0.96 (0.05, 16.78)

SIRT_Sorafenib

  0.43 (0.1, 1.79)

0.49 (0.12, 2.2)

0.61 (0.06, 5.99)

0.67 (0.12, 3.42)

0.7 (0.05, 10.07)

Sorafenib

  0.31 (0.02, 4.48)

0.36 (0.03, 5.42)

0.44 (0.02, 10.59)

0.49 (0.03, 7.61)

0.51 (0.01, 16.78)

0.73 (0.08, 6.89)

Lenvatinib

  0.17 (0.02, 1.49)

0.2 (0.02, 1.84)

0.25 (0.01, 3.86)

0.27 (0.02, 2.61)

0.28 (0.01, 6.3)

0.4 (0.07, 2.08)

0.55 (0.03, 8.58)

HAIC_Sorafenib

  0.15 (0.02, 0.9)

0.16 (0.02, 1.07)

0.21 (0.01, 3.13)

0.23 (0.05, 0.76)

0.23 (0.01, 4.18)

0.34 (0.05, 1.68)

0.46 (0.02, 6.89)

0.84 (0.07, 8.67)

TACE_Sorafenib

  0.08 (0, 1.57)

0.09 (0, 1.88)

0.11 (0, 4.18)

0.12 (0.01, 1.72)

0.12 (0, 5.16)

0.17 (0.01, 3.19)

0.24 (0.01, 9.21)

0.43 (0.01, 12.81)

0.52 (0.04, 6.05)

TACE_Lenvatinib

ORR mRECIST

 SIRT

  0 (0, 0.85)

Sorafenib

  0 (0, 0.25)

0.28 (0.04, 1.86)

Lenvatinib

  0 (0, 0.17)

0.23 (0.02, 2.14)

0.81 (0.07, 9.39)

TACE

  0 (0, 0.15)

0.2 (0.02, 2.12)

0.7 (0.06, 8.17)

0.87 (0.21, 3.71)

TACE_Sorafenib

  0 (0, 0.14)

0.15 (0.05, 0.45)

0.55 (0.06, 5.16)

0.68 (0.06, 8.94)

0.78 (0.06, 11.47)

HAIC_Sorafenib

  0 (0, 0.08)

0.1 (0.02, 0.49)

0.37 (0.04, 3.49)

0.45 (0.07, 2.97)

0.52 (0.05, 4.53)

0.66 (0.08, 4.44)

HAIC

  0 (0, 0.06)

0.07 (0.01, 0.7)

0.24 (0.04, 1.67)

0.3 (0.03, 2.92)

0.35 (0.04, 2.69)

0.44 (0.03, 5.75)

0.67 (0.06, 8.25)

TACE_Lenvatinib

DCR mRECIST

 Sorafenib

  0.61 (0.06,5.31)

TACE

  0.57 (0.05,5.64)

0.93 (0.23,3.82)

TACE_Sorafenib

  0.52 (0.08,3.25)

0.84 (0.08,10.28)

0.9 (0.08,10.91)

Lenvatinib

  0.53 (0.17,1.52)

0.87 (0.08,10.18)

0.92 (0.07,12.55)

1.02 (0.12,8.58)

HAIC_Sorafenib

  0.25 (0.05,1.02)

0.41 (0.06,2.69)

0.44 (0.05,3.86)

0.49 (0.05,4.06)

0.48 (0.07,2.86)

HAIC

  0.09 (0.01,0.89)

0.15 (0.01,1.52)

0.16 (0.02,1.38)

0.17 (0.02,1.17)

0.17 (0.01,2.23)

0.36 (0.03,4.14)

TACE_Lenvatinib

ORR RECIST

 Sorafenib

  0.59 (0.03,10.8)

Lenvatinib

  0.57 (0.02,15.33)

0.97 (0.01,81.45)

Donafenib

  0.23 (0.02,2.2)

0.39 (0.01,16.12)

0.4 (0.01,21.12)

SIRT

  0.18 (0,14.3)

0.3 (0.01,7.77)

0.31 (0,72.24)

0.79 (0.01,119.1)

TACE_Lenvatinib

  0.1 (0.01,0.88)

0.17 (0.01,3.39)

0.18 (0,8.76)

0.44 (0.02,11.25)

0.56 (0.01,45.15)

TACE_Sorafenib

  0.1 (0.01,0.98)

0.17 (0.01,3.32)

0.17 (0,9.3)

0.43 (0.02,12.43)

0.54 (0.01,42.95)

0.96 (0.11,7.92)

TACE

  0.03 (0,0.39)

0.05 (0,2.59)

0.06 (0,3.56)

0.14 (0,4.57)

0.18 (0,27.94)

0.32 (0.01,8)

0.33 (0.01,9.78)

HAIC_Sorafenib

  0.03 (0,0.37)

0.04 (0,1.67)

0.05 (0,3.03)

0.11 (0,4.14)

0.14 (0,18.54)

0.25 (0.01,4.81)

0.26 (0.02,3.6)

0.79 (0.02,35.16)

HAIC

DCR RECIST

 SIRT

  0.76 (0.29, 2.05)

Sorafenib

  0.7 (0.13, 3.74)

0.9 (0.23, 3.49)

Donafenib

  0.51 (0.12, 2.59)

0.66 (0.21, 2.41)

0.73 (0.13, 5.05)

Lenvatinib

  0.42 (0.11, 1.73)

0.54 (0.2, 1.52)

0.61 (0.12, 3.35)

0.82 (0.22, 2.75)

TACE

  0.38 (0.1, 1.39)

0.49 (0.19, 1.2)

0.54 (0.1, 2.75)

0.73 (0.2, 2.32)

0.9 (0.34, 2.23)

TACE_Sorafenib

  0.2 (0.05, 0.9)

0.26 (0.09, 0.83)

0.29 (0.05, 1.73)

0.4 (0.08, 1.72)

0.49 (0.16, 1.49)

0.54 (0.16, 2.03)

HAIC

  0.17 (0.04, 0.69)

0.23 (0.07, 0.61)

0.25 (0.04, 1.31)

0.34 (0.06, 1.46)

0.41 (0.08, 1.63)

0.46 (0.1, 1.79)

0.86 (0.16, 3.67)

HAIC_Sorafenib

  0.11 (0.01, 0.98)

0.14 (0.02, 1.02)

0.16 (0.02, 1.77)

0.21 (0.05, 0.93)

0.26 (0.04, 1.84)

0.29 (0.05, 2.16)

0.54 (0.07, 4.66)

0.63 (0.08, 6.42)

TACE_Lenvatinib