Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
Age | 3881 | ||||
< 65 | 1708 | Reference | |||
≥ 65 | 2173 | 1.46 (1.35–1.59) | < 0.01 | 1.37 (1.26–1.49) | < 0.01 |
Sex | 3881 | ||||
Female | 2132 | Reference | |||
Male | 1749 | 1.39 (1.28–1.50) | < 0.01 | 1.37 (1.26–1.49) | < 0.01 |
Year of diagnosis | 3881 | ||||
2000–2009 | 1747 | Reference | |||
2010–2019 | 2134 | 0.54 (0.50–0.59) | < 0.01 | 0.56 (0.52–0.61) | < 0.01 |
Race | 3881 | ||||
White | 3126 | Reference | |||
Other | 755 | 0.78 (0.70–0.86) | < 0.01 | 0.81 (0.73–0.90) | < 0.01 |
Primary site | 3881 | ||||
Upper lobe | 2421 | Reference | |||
Middle lobe | 202 | 1.01 (0.84–1.21) | 0.92 | 1.17 (0.97–1.41) | 0.10 |
Lower lobe | 1258 | 1.04 (0.95–1.13) | 0.44 | 1.06 (0.97–1.160) | 0.18 |
Laterality | 3881 | ||||
Left | 1764 | Reference | |||
Right | 2117 | 0.94 (0.87–1.02) | 0.11 | 0.94 (0.88–1.02) | 0.14 |
Histologic type | 3881 | ||||
LUAD | 2777 | Reference | |||
LUSC | 658 | 1.30 (1.17–1.45) | < 0.01 | 1.17 (1.04–1.30) | 0.01 |
Large cell | 114 | 1.34 (1.07–1.67) | 0.01 | 1.25 (1.00–1.57) | 0.05 |
Other | 332 | 1.01 (0.87–1.17) | 0.91 | 1.00 (0.86–1.16) | 0.99 |
T stage | 3881 | ||||
T1 | 1532 | Reference | |||
T2 | 2349 | 1.26 (1.16–1.37) | < 0.01 | 1.260 (1.16–1.37) | < 0.01 |
Surgery | 3881 | ||||
Lobectomy | 3259 | Reference | |||
Sublobectomy | 405 | 1.33 (1.17–1.50) | < 0.01 | 1.45 (1.27–1.64) | < 0.01 |
Pneumonectomy | 217 | 1.31 (1.12–1.53) | < 0.01 | 0.95 (0.80–1.13) | 0.55 |
Surg/Rad Seq | 3881 | ||||
Non-PORT | 2214 | Reference | |||
PORT | 1667 | 0.92 (0.85–1.01) | 0.06 | 1.03 (0.94–1.12) | 0.56 |
Chemotherapy | 3881 | ||||
No | 1180 | Reference | |||
Yes | 2701 | 0.61 (0.56–0.66) | < 0.01 | 0.70 (0.64–0.77) | < 0.01 |
Regional nodes positive | 3881 | ||||
< 4 | 2505 | Reference | |||
≥ 4 | 1376 | 1.40 (1.29–1.51) | < 0.01 | 1.51 (1.38–1.64) | < 0.01 |