Fig. 3

Screening hypoxia-relevant genes and definition of a hypoxia-relevant prognostic signature in TCGA-LIHC dataset. A Expression difference of hypoxia genes in cluster1 versus cluster2. B, C Identifying hypoxia-relevant genes with differential expression between cluster1 and cluster2. D The top 20 hypoxia-relevant genes in cluster1 and cluster2. E LASSO coefficient results based upon prognostic hypoxia-relevant genes. F Ten-fold cross-validation. G Univariate-cox regression results of genes screened by LASSO. H Expression of identified genes in hypoxia-relevant risk score. I Distribution of hypoxia-relevant risk score. J-L K-M curves of OS in high- versus low-risk patients in the training, test and total datasets