From: Prognostic analysis of patients with stage IIIC1p cervical cancer treated by surgery
Variables | OS | DFS | ||
---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Age (reference: ≤ 54) | 0.738(0.375 ~ 1.454) | 0.380 | 0.688(0.351 ~ 1.350) | 0.276 |
Postoperative treatment (reference: none) | - | - | - | - |
 Chemotherapy | 0.327(0.152 ~ 0.705) | 0.004 | 0.381(0.177 ~ 0.821) | 0.014 |
 Chemo plus radiotherapy | 0.061(0.024 ~ 0.157) |  < 0.001 | 0.078(0.031 ~ 0.197) |  < 0.001 |
Surgical method (reference: laparoscope) | 0.760(0.353 ~ 1.636) | 0.483 | 0.695(0.319 ~ 1.515) | 0.361 |
Ovarian status (reference: ovarian transposition) | 2.585(1.090 ~ 6.130) | 0.031 | 2.388(1.060 ~ 5.381) | 0.036 |
Intraoperative blood loss (ml) (reference: ≤ 250) | 1.690(0.911 ~ 3.134) | 0.096 | 1.588(0.861 ~ 2.927) | 0.139 |
Perioperative complications (reference: none) | 2.277(1.249 ~ 4.150) | 0.007 | 2.102(1.159 ~ 3.813) | 0.014 |
Pathological type (reference: squamous cell carcinoma) | - | - | - | - |
 Adenocarcinoma | 1.197(0.555 ~ 2.581) | 0.646 | 1.098(0.511 ~ 2.359) | 0.811 |
 Adeno-squamous carcinoma | 1.276(0.392 ~ 4.158) | 0.686 | 1.185(0.364 ~ 3.851) | 0.778 |
Tumor size (cm) (reference: ≤ 4) | 1.564(0.875 ~ 2.796) | 0.131 | 1.519(0.861 ~ 2.679) | 0.149 |
LNR (reference: ≤ 0.3) | 4.643(2.572 ~ 8.381) |  < 0.001 | 4.490(2.505 ~ 8.050) |  < 0.001 |
DSI (reference: ≤ 1/2) | 3.208(0.774 ~ 13.294) | 0.108 | 3.620(0.866 ~ 15.136) | 0.078 |
LVSI (reference: negative) | 2.283(1.192 ~ 4.371) | 0.013 | 2.013(1.070 ~ 3.787) | 0.030 |
Vaginal margin (reference: negative) | 1.607(0.901 ~ 2.866) | 0.108 | 1.507(0.853 ~ 2.663) | 0.158 |
Parametrium (reference: negative) | 2.381(1.108 ~ 5.113) | 0.026 | 2.621(1.264 ~ 5.434) | 0.010 |
NLR (reference: ≤ 3.8) | 2.694(1.357 ~ 5.349) | 0.005 | 3.397(1.745 ~ 6.612) |  < 0.001 |