Table 2 Characteristics of patients without (group I) and with (group II) hemodynamic instability (HI)
Characteristics | Group I (n = 28) | Group II (n = 12) | P value |
|---|---|---|---|
Male, n (%) | 12 (42.9) | 6 (50.0) | 0.471 |
Age at diagnosis PHEO/PGL | 50.61 ± 16.20 | 51.25 ± 22.18 | 0.919 |
Extra-adrenal localization (%) | 4/28 (14.3) | 2/12 (16.7) | 0.595 |
Tumor size (mm) | 37.00 ± 16.22 | 44.33 ± 15.51 | 0.192 |
Cluster | 0.896 | ||
1 | 4 (16.00) | 1 (10.00) | |
2 | 5 (20.00) | 2 (20.00) | |
wt | 16 (64.00) | 7 (70.00) | |
Mean doxazosin daily dose (mg/die) | 4.68 ± 2.75 | 5.42 ± 3.15 | 0.461 |
Urinary metanephrine (µg/24 h) | 519 [125.25–1283.25] | 513 [219–2421.25] | 0.497 |
Urinary normetanephrine (µg/24 h) | 959.0 [559.50–2641.25] | 2047 [1059.25–5601.50] | 0.039 |
Pre-surgical SBP (mmHg) | 123.9 ± 14.8 | 134.7 ± 17.5 | 0.0051 |
Pre-surgical DBP (mmHg) | 76.46 ± 11.20 | 75.00 ± 11.48 | 0.918 |
Pre-surgical MBP (mmHg) | 92.32 ± 11.54 | 94.83 v 11.34 | 0.668 |
Adequate preparation (%) | 25 (89.30) | 6 (50.00) | 0.012 |
Preoperative antihypertensive therapy | 0.311 | ||
Alpha blockers, n (%) | 19 (67.9%) | 6 (50%) | |
Alpha blockers + others, n (%) | 9 (32%) | 6 (50%) | |
ASA Physical Status Classification System, n (%) | I 9 (32.1) | I 5 (41.7) | 0.568 |
II 19 (67.9) | II 7 (58.3) | ||
Laparoscopic approach (%) | 26 (92.90) | 10 (83.30) | 0.346 |
Surgery time (min) | 107.50 [81.25–138.75] | 130.00 [102.50–206.25] | 0.021 |
Intraoperative drugs (%) | 7 (25.00) | 10 (83.30) | < 0.001 |
Nitrates | 0 (0%) | 2 (16.7%) | |
Alpha-blockers | 2 (7.1%) | 4 (33.3%) | |
Beta-blockers | 2 (7.1%) | 0 (0%) | |
Alpha blockers plus sympathomimetic drugs | 1 (3.6%) | 0 (0%) | |
Nitrates plus alpha blockers | 1 (3.6%) | 0 (0%) | |
Nitrates plus alpha-blockers plus beta-blockers | 0 (0%) | 1 (8.3%) | |
Beta-blockers plus sympathomimetic drugs | 0 (0%) | 2 (16.7%) | |
Beta-blockers plus nitrates | 1 (3.6%) | 0 (0%) | |
Alpha-blockers plus beta-blockers plus sympathomimetic drugs | 0 (0%) | 1 (8.3%) | |
Intraoperative SBP (mmHg) | 117.77 ± 7.52 | 141.48 ± 14.47 | < 0.001 |
Intraoperative DBP (mmHg) | 68.33 ± 7.17 | 82.14 ± 10.56 | < 0.001 |
Intraoperative MBP (mmHg) | 84.81 ± 6.04 | 101.92 ± 10.76 | < 0.001 |
Cardiological comorbidities (%) | 2 (7.10) | 4 (33.30) | 0.055 |