Table 3 Analysis of interaction between rs3740535 genotypes and family history of cancer
Implicit model | Additive model | ||||
|---|---|---|---|---|---|
Genotype | Family history of cancer | αHR (95%CI)* | Genotype | Family history of cancer | αHR (95%CI)* |
AG + GG | No | 1 | AA | No | 1 |
AG + GG | Other tumors | 0.969(0.761–1.234) | AA | Other tumors | 0.906(0.678–1.210) |
AG + GG | Lung cancer | 1.129(0.810–1.572) | AA | Lung cancer | 1.179(0.752–1.847) |
AA | No | 0.949(0.669–1.346) | GG | No | 1.009(0.706–1.443) |
AA | Other tumors | 0.677(0.347–1.321) | GG | Other tumors | 0.704(0.358–1.385) |
AA | Lung cancer | 2.047(0.744–5.637) | GG | Lung cancer | 2.130(0.758–5.981) |
Multiplication interaction | 1.035(0.912–1.175) | Multiplication interaction | 1.019(0.873–1.190) | ||
Relative excess risk (RERI) | 0.125(− 0.434–0.685) | Relative excess risk (RERI) | 0.121(− 0.434–0.675) | ||
Attributable risk percent (ARP) | 0.203(− 0.594–1.001) | Attributable risk percent (ARP) | 0.207(− 0.692–1.106) | ||
Synergic index (S) | 0.754(0.172–3.307) | Synergic index (S) | 0.775(0.205–2.931) | ||