Table 2 The association of SNPs with the overall survival of lung cancer patients
Genetic locus | Genotype | Lung cancer | ||
|---|---|---|---|---|
Deaths/total number | Log rank P | αHR (95%CI)* | ||
rs13409 | ||||
Co-dominance | CC | 396/507 | 0.965 | 1 |
CT | 292/379 | 0.948(0.815–1.104) | ||
TT | 87/116 | 0.919(0.728–1.161) | ||
Dominance | CC | 396/507 | 0.831 | 1 |
CT + TT | 379/495 | 0.941(0.817–1.084) | ||
Recessiveness | CC + CT | 688/886 | 0.819 | 1 |
TT | 87/116 | 0.940(0.752–1.177) | ||
Additivity | 0.792 | 0.928(0.735–1.172) | ||
rs6815391 | ||||
Co-dominance | TT | 365/473 | 0.541 | 1 |
CT | 333/433 | 1.075(0.926–1.249) | ||
CC | 78/99 | 1.180(0.924–1.508) | ||
Dominance | TT | 365/473 | 0.347 | 1 |
CC + CT | 411/532 | 1.094(0.949–1.260) | ||
Recessiveness | CT + TT | 698/906 | 0.395 | 1 |
CC | 78/99 | 1.141(0.902–1.442) | ||
Additivity | 0.292 | 1.169(0.915–1.494) | ||
rs3740535 | ||||
Co-dominance | GG | 467/587 | 0.667 | 1 |
AG | 275/366 | 0.948(0.816–1.101) | ||
AA | 58/74 | 0.889(0.676–1.169) | ||
Dominance | GG | 467/587 | 0.371 | 1 |
AA + AG | 333/440 | 0.937(0.814–1.079) | ||
Recessiveness | AG + GG | 742/953 | 0.846 | 1 |
AA | 58/74 | 0.907(0.694–1.186) | ||
Additivity | 0.721 | 0.895(0.680–1.177) | ||
rs3130932 | ||||
Co-dominance | TT | 350/442 | 0.497 | 1 |
GT | 101/451 | 0.959(0.827–1.113) | ||
GG | 92/129 | 0.804(0.638–1.013) | ||
Dominance | TT | 350/442 | 0.299 | 1 |
GG + GT | 440/580 | 0.923(0.802–1.062) | ||
Recessiveness | GT + TT | 698/893 | 0.382 | 1 |
GG | 92/129 | 0.821(0.660–1.022) | ||
Additivity | 0.285 | 0.810(0.643–1.022) | ||