Table 3 Univariate and multivariate analysis for overall survival

Gender (male vs female)

1.513 (0.859–2.663)

0.152

2.026 (0.945–4.344)

0.070

Age (years, < 60 vs ≥ 60)

0.285 (0.147–0.553)

< 0.01

0.300 (0.150–0.600)

0.001

BMI

 < 18.5

Ref

-

Ref

-

 18.5–23.9

0.697 (0.311–1.563)

0.381

0.562 (0.240–0.319)

0.186

 ≥ 24

0.440 (0.167–1.156)

0.096

0.374 (0.126–0.958)

0.041

Smoking (yes vs no)

0.973 (0.565–1.674)

0.920

0.413 (0.179–0.952)

0.038

Drinking (yes vs no)

1.134 (0.653–1.971)

0.655

1.362 (0.609–3.045)

0.452

Family history of cancer (yes vs no)

1.371 (0.428–4.395)

0.595

1.523 (0.453–5.115)

0.496

Adjuvant therapy (yes vs no)

0.932 (0.533–1.628)

0.803

0.869 (0.476–1.588)

0.649

Tumor stage

 I

Ref

-

Ref

-

 II

2.759 (1.045–7.286)

0.041

2.473 (0.908–6.738)

0.077

 III

4.510 (1.736–11.718)

0.002

5.392 (2.013–14.444)

0.001

Tumor site

 Others^a

Ref

-

Ref

-

 Rectum

0.261 (0.091–0.747)

0.012

0.650 (0.195–2.164)

0.482

 Colon

0.257 (0.088–0.753)

0.013

0.485 (0.150–1.570)

0.227

 SIRI (< 1.1 vs ≥ 1.1)

0.446 (0.261–0.761)

0.003

NI

CEA

NI

 < 4.1 ng/l

Ref

-

 4.1–13.0 ng/l

0.954 (0.496–1.836)

0.888

 ≥ 13.0 ng/l

2.289 (1.206–4.345)

0.011

C-SIRI score

 0/1

Ref

-

Ref

-

 2/3

2.782 (1.630–4.746)

< 0.001

2.563 (1.419–4.628)

0.002