Fig. 3From: Histological transformation to signet-ring cell carcinoma in a patient with clinically aggressive poorly differentiated adenocarcinoma of the ascending colon after response to chemotherapy plus cetuximab: a case reportHistopathology and immunostaining of ascending colon biopsy specimens. Hematoxylin and eosin staining (A) and immunostaining for CK AE1/AE3 (B), CDX2 (C), and CD45 (D). Tumor cells show poorly differentiated adenocarcinoma-like findings (A). These cells are positive for CK AE1/AE3 (B) and CDX2 (C) and negative for CD45 (D). A–D Original magnification × 200. Each bar displayed at the bottom right indicates 200 μmBack to article page