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Table 3 Univariate and binary logistic models for local recurrence and metastasis

From: Does joint-sparing tumor resection jeopardize oncologic and functional outcomes in non-metastatic high-grade osteosarcoma around the knee?

 

Univariate models

Multivariate binary logistic model

Univariate models

 

Multivariate binary logistic model

Variable

Local recurrence

 

p value

OR

95% CI

p value

Metastasis

 

p value

OR

95% CI

p value

 

Yes

No

    

Yes

No

    

Age

  ≤ 15

8 (80%)

45 (56.9%)

    

17 (68%)

36 (56.3%)

  

  > 15

2 (20%)

34 (43.1%)

0.193

   

8 (32%)

28 (43.7)

0.346

 

Gender

 Male

7 (70%)

42 (53.2%)

    

16 (64%)

33 (51.6%)

  

 Female

3 (30%)

37 (46.8%)

0.254

   

9 (36%)

31 (48.4%)

0.206

 

Anatomic location

 Femur

5 (50%)

51 (64.6%)

    

17 (68%)

39 (60.9%)

  

 Tibia

5 (50%)

28 (35.4%)

0.286

   

8 (32%)

25 (39.1%)

0.357

 

Plain radiographic pattern

 Blastic

4 (40%)

37 (46.8%)

    

9 (36%)

32 (50%)

  

 Lytic or mixed

6 (60%)

42 (53.2%)

0.474

   

16 (64%)

32 (50%)

0.17

 

Epiphysis involvement

 No involvement

1 (10%)

18 (22.8%)

    

2 (8%)

17 (26.6%)

  

 Involvement

9 (90%)

61 (77.2%)

0.321

   

23 (92%)

47 (73.4%)

0.045

 

Pathologic fracture

 No

8 (80%)

77 (97.5%)

    

24 (96%)

61 (95.3%)

  

 Yes

2 (20%)

2 (2.5%)

0.061

   

1 (4%)

3 (4.7%)

0.687

 

Perivascular space change

 Stable

9 (90%)

58 (73.4%)

    

8 (32%)

59 (92.2%)

    

 Progressed

1 (10%)

21 (26.6%)

0.234

   

17 (68%)

5 (7.8%)

< 0.001 

93.863

10.537–836.106

< 0.001

Limb diameter increase

 Stable

4 (40%)

56 (70.9%)

    

9 (36%)

51 (79.7%)

< 0.001

   

 Increased

6 (60%)

23 (29.1%)

0.058

   

16 (64%)

13 (20.3%)

 

31.016

3.703–259.793

0.002

Bony resection margin

 Wide

7 (70%)

44 (55.7%)

    

16 (64%)

35 (54.7%)

  

 Limited wide

2 (20%)

15 (19%)

    

4 (16%)

13 (20.3%)

  

 Ablated

1 (10%)

20 (25.3%)

0.496

   

5 (20%)

16 (25%)

0.725

 

Soft tissue margin

 Wide

5 (50%)

69 (87.3%)

    

19 (76%)

55 (85.9%)

  

 Marginal

5 (50%)

10 (12.7%)

0.011

8.982

1.869–43.171

0.006

6 (24%)

9 (14.1%)

0.206

 

Native joint status

 Preservation

4 (40%)

43 (54.4%)

    

11 (44%)

36 (56.2%)

  

 Resection

6 (60%)

36 (45.6%)

0.3

   

14 (56%)

28 (43.8%)

0.211

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