Table 4 Univariable and multivariable Cox proportional hazards regression analysis for intrahepatic recurrence-free survival in all the patients

Age (years) (≤ 60/ > 60)

0.759 (0.565–1.019)

0.067*

Sex (F/M)

1.163 (0.855–1.580)

0.336

BMI (kg/m²) (≤ 25/ > 25)

1.472 (1.080–2.008)

0.014*

Primary CRC

 CRC grade (WD-MD/PD)

1.159 (0.570–2.353)

0.684

 CRC T stage (T1–2/T3–4)

1.659 (0.877–3.140)

0.120

 CRC N stage (N0/N +)

2.001 (1.414–2.833)

< 0.001*

2.201 (1.540–3.146)

< 0.001

 CRC resection status (R0/R1)

1.535 (0.873–2.698)

0.136

 CRC location

  Right colon

1 (reference)

  Left colon

0.669 (0.445–1.007)

0.054

  Rectum

0.864 (0.575–1.299)

0.483

Liver metastatic tumor

 Liver resection margin status (R0/R1)

1.180 (0.824–1.691)

0.367

 Liver tumor size(cm) (< 5/ ≥ 5)

1.289 (0.810–2.049)

0.284

 Number of liver tumor (≤ 3/ ≥ 4)

2.425 (1.815–3.242)

< 0.001*

1.542 (1.069–2.223)

0.020

 Tumor burden score

  Zone 1

1 (reference)

< 0.001*

  Zone 2

1.663 (1.147–2.410)

0.007*

  Zone 3

3.966 (2.412–6.523)

< 0.001*

2.289 (1.232–4.253)

0.009

 Initial CEA (≤ 50/ > 50)

1.643 (1.209–2.233)

0.002*

 Necrosis (n = 308) (≤ 20/ > 20%)

0.857 (0.629–1.168)

0.329

 Extent of liver resection

  Minor/major

1.061 (0.788–1.429)

0.696

 Bilobar disease (N/Y)

2.037 (1.525–2.720)

< 0.001*

 Non-tumor histology

  Normal

0.066*

  Steatosis

1.171 (0.847–1.620)

0.338

  Steatohepatitis

2.093 (1.144–3.829)

0.016

  Sinusoidal obstruction syndrome

1.542 (0.976–2.436)

0.064*

 Intraoperative transfusion (N/Y)

1.033 (0.726–1.469)

0.858

 Preoperative chemotherapy (N/Y)

1.988 (1.482–2.666)

< 0.001*

1.526 (1.103–2.112)

0.011

 Preoperative target therapy (N/Y)

1.593 (1.175–2.160)

0.003*

 Adjuvant chemotherapy (N/Y)

0.559 (0.361–0.866)

0.009*

0.488 (0.308–0.771)

0.002