Table 3 Univariable and multivariable Cox proportional hazards regression analysis for overall survival in all the patients

Age (years) (≤ 60/ > 60)

0.959 (0.652–1.409)

0.830

Sex (F/M)

0.890 (0.600–1.319)

0.561

BMI (kg/m²) (≤ 25/ > 25)

1.135 (0.737–1.747)

0.566

Initial CEA (≤ 50/ > 50)

1.456 (0.980–2.164)

0.063*

Primary CRC

 CRC grade (WD-MD/PD)

4.453 (2.306–8.597)

< 0.001*

5.483 (2.670–11.262)

 < 0.001

 CRC T stage (T1–2/T3–4)

3.027 (0.960–9.549)

0.059*

 CRC N stage (N0/N +)

2.871 (1.663–4.958)

< 0.001*

3.136 (1.748–5.626)

 < 0.001

 CRC resection status (R0/R1)

1.987 (1.003–3.936)

0.049*

 CRC location

  Right colon

1 (reference)

  Left colon

0.642 (0.378–1.089)

0.100

  Rectum

0.887 (0.529–1.487)

0.650

Liver metastatic tumor

 Liver resection margin status (R0/R1)

0.655 (0.366–1.170)

0.152

 Number of liver tumor (≤ 3/ ≥ 4)

1.759 (1.195–2.591)

0.004*

1.851 (1.230–2.786)

0.003

 Liver tumor size (cm) (< 5/ ≥ 5)

2.437 (1.525–3.896)

< 0.001*

2.713 (1.670–4.408)

 < 0.001

 Tumor burden score

  Zone 1

1 (reference)

< 0.001*

  Zone 2

1.764 (1.051–2.961)

0.032

  Zone 3

4.608 (2.412–8.804)

< 0.001

 Extent of liver resection

 Minor/major

1.282 (0.871–1.888)

0.208

 Bilobar disease

1.430 (0.979–2.090)

0.064*

 Necrosis (n = 308) (≤ 20/ > 20%)

0.902 (0.599–1.358)

0.621

 Non-tumor histology

  Normal

0.246

  Steatosis

0.729 (0.464–1.144)

0.169

 Steatohepatitis

0.881 (0.276–2.810)

0.830

  Sinusoidal obstruction syndrome

1.398 (0.783–2.498)

0.257

 Intraoperative transfusion (N/Y)

1.440 (0.931–2.228)

0.101

 Preoperative chemotherapy (N/Y)

1.167 (0.798–1.707)

0.425

 Preoperative target therapy (N/Y)

1.043 (0.665–1.636)

0.854

 Adjuvant chemotherapy (N/Y)

0.498 (0.288–0.860)

0.012*

0.465 (0.259–0.837)

0.011