Table 2 Comparison between adjacent normal, adenoma, and carcinoma cases according to DDR1 and β-catenin immunostaining (n = 76)

EpithelialDDR1

Intensity

 Negative

2 (25%)

1 (5.0%)

0 (0%)

MH

0.035^a

MH 0.046^a

MH 0.032^a

 Mild

2 (25%)

11 (55%)

22 (45.8%)

 Moderate

2 (25%)

8 (40%)

13 (27.1%)

 Strong

2 (25%)

0 (0.0%)

13 (27.1%)

Localization

n = 6

n = 19

n = 48

MH < 0.0001^a

MH 0.739

NA

 C

1 (16.7%)

19 (100%)

37 (77.1%)

 M

1 (16.7%)

0 (0%)

0 (0%)

 MC

4 (66.7%)

0 (0%)

11 (22.9%)

H-score

n = 6

n = 19

n = 48

 Mean ± SD

20 ± 8.9

81.5 ± 42.2

137.4 ± 96.9

U 0.001^a

Z 0.027^a

U 0.042^a

 Median (min.–max.)

20 (10–30)

80 (10–160)

140 (10–300)

Extent (%)

n = 6

n = 19

n = 48

 Mean ± SD.

10 ± 0

64.1 ± 32.8

NA

Z 0.024*

NA

 Median (min.–max.)

10 (10-10)

NA

80 (10–100)

Epithelial β-catenin

Expression

 Negative

2 (10%)

15 (31.3%)

Χ² 0.06

 Positive

18 (90%)

33 (68.8%)

Intensity

n = 18

n = 33

 Mild

8 (44.4%)

15 (45.5%)

Χ² 1.0

 Moderate

8 (44.4%)

13 (39.4%)

 Strong

2 (11.1%)

5 (15.2%)

Localization

n = 18

n = 33

 C

18 (100%)

25 (75.8%)

Χ² 0.103

 NC

0 (0%)

3 (9.4%)

 MC

0 (0%)

5 (15.6%)

H-score

n = 18

n = 33

 Mean ± SD

113.3 ± 73.8

126.7 ± 77.24

U 0.422

 Median (min.–max.)

130 (20-240)

160 (20-270)

Extent/percent (%)

n = 18

n = 33

 Mean ± SD

61.7 ± 25.5

68.8 ± 23.3

U 0.194

 Median (min.–max.)

70 (20–90)

80 (20–90)