The use of adjuvant chemotherapy is not associated with recurrence or cancer-specific death following curative resection for stage III rectal cancer: a competing risks analysis

Table 5 Association between adjuvant chemotherapy and overall survival and between other variables independently associated with administration of AC and death due to any cause

	Category^a	Censored n = 160	Died of any cause n = 178	Bivariate hazard ratio (95% CI)	Wald P	Multivariable hazard ratio (95% CI)	Wald P
Adjuvant chemotherapy	No	35	95	REF	<0.001		0.009
Adjuvant chemotherapy	Yes	125	83	0.43 (0.32–0.57)		0.61 (0.43–0.88)	0.009
Year of resection	1995–1999	18	61	0.79 (0.69–0.91)	0.001	0.83 (0.72–0.96)	0.013
	2000–2004	33	50
	2005–2009	41	42
	2010–2014	24	21
	2015–2019	44	4
Age	< 75 years	142	125	REF	<0.001		0.024
Age	≥ 75 years	18	53	2.17 (1.57–3.00)		1.54 (1.06–2.26)	0.024
Peripheral vascular disease	No	159	163	REF	<0.001		0.003
Peripheral vascular disease	Yes	1	15	3.39 (1.99–5.80)		2.30 (1.32–4.02)	0.003
Intra-abdominal or pelvic abscess/haematoma	No	145	166	REF	0.833	–	–
Intra-abdominal or pelvic abscess/haematoma	Yes	15	12	0.94 (0.52–1.69)

Italicized P values indicate P significance at ≤ 0.05
RC rectal cancer, CI confidence interval
^aIn each cell, first line is the reference category coded 0, second line is the category of interest coded 1

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