Table 1 Characteristics of patients with metastatic neuroblastoma
From: Metastasis pattern and prognosis in children with neuroblastoma
Variable | N (%) | NB with metastasis, N (%) | NB without metastasis, N (%) | P |
|---|---|---|---|---|
Total | 1224 (100.0) | 599 (100.0) | 625 (100.0) | Â |
Age (years) |  |  |  |  < 0.001 |
 ≤ 1 | 611 (49.9) | 257 (42.9) | 354 (56.6) |  |
 > 1 | 613 (50.1) | 342 (57.1) | 271 (43.4) |  |
Gender | Â | Â | Â | 0.024 |
 Male | 632 (51.6) | 329 (54.9) | 303 (48.5) |  |
 Female | 592 (48.4) | 270 (45.1) | 322 (51.5) |  |
Race | Â | Â | Â | 0.338 |
 White | 884 (72.2) | 432 (72.1) | 452 (72.3) |  |
 Black | 194 (15.8) | 102 (17.0) | 92 (14.7) |  |
 Others/unknown | 146 (11.9) | 65 (10.9) | 81 (13.0) |  |
Primary site |  |  |  |  < 0.001 |
 Adrenal | 577 (47.1) | 387 (64.6) | 190 (30.4) |  |
 Soft tissue | 304 (24.8) | 213 (35.6) | 91 (14.6) |  |
 Retroperitoneum | 124 (10.1) | 53 (8.8) | 71 (11.4) |  |
 Others | 219 (17.9) | 68 (11.4) | 151 (24.2) |  |
Tumour grade | Â | Â | Â | 0.240 |
 Grades I–II | 15 (1.2) | 4 (0.7) | 11 (1.8) |  |
 Grades III–IV | 608 (49.7) | 316 (52.8) | 292 (46.7) |  |
 Unknown | 611 (49.9) | 279 (46.6) | 332 (53.1) |  |
Laterality |  |  |  |  < 0.001 |
 Unilateral | 709 (57.9) | 428 (71.5) | 281 (45.0) |  |
 Bilateral | 27 (2.2) | 15 (2.5) | 12 (1.9) |  |
 Unknown | 488 (39.9) | 156 (26.0) | 332 (53.1) |  |
Tumour size (cm) |  |  |  |  < 0.001 |
 5 | 221 (18.1) | 75 (12.5) | 146 (23.4) |  |
 5–10 | 318 (26.0) | 157 (26.2) | 161 (25.8) |  |
 10 | 141 (11.5) | 88 (14.7) | 53 (8.5) |  |
 Unknown | 544 (44.4) | 279 (46.6) | 265 (42.4) |  |
Histology |  |  |  |  < 0.001 |
 Neuroblastoma-NOS | 1003 (81.9) | 563 (94.0) | 440 (70.4) |  |
 Ganglioneuroblastoma | 221 (18.1) | 36 (6.0) | 185 (29.6) |  |
Chemotherapy |  |  |  |  < 0.001 |
 Yes | 829 (67.7) | 565 (94.3) | 264 (42.2) |  |
 No | 395 (32.3) | 34 (5.7) | 361 (57.8) |  |
Surgery | Â | Â | Â | 0.001 |
 Yes | 939 (76.7) | 436 (72.8) | 503 (80.5) |  |
 No | 285 (23.3) | 163 (27.2) | 122 (19.5) |  |
Radiotherapy |  |  |  |  < 0.001 |
 Yes | 321 (26.2) | 259 (43.2) | 62 (9.9) |  |
 No | 903 (73.8) | 340 (56.8) | 563 (90.1) |  |
SMN |  |  |  |  < 0.001 |
 Yes | 25 (2.0) | 21 (3.5) | 4 (0.6) |  |
 No | 1199 (98.0) | 578 (96.5) | 621 (99.4) |  |