Fig. 1

Upregulated lncRNA MRVI1-AS1 indicates poor prognosis of HCC. A RNA-seq analysis was used to identify the differentially expressed lncRNAs in HCC tissues (n = 3) and adjacent non-tumor (NT) tissues (n = 3), and the upregulated lncRNAs in HCC were shown as heat map. B RT-qPCR was conducted to explore the expression of MRVI1-AS1 in HCC tissues (n = 72) and adjacent non-tumor (NT) tissues (n = 72). *P < 0.05, Student’s t test. C TCGA data from GEPIA platform showed MRVI1-AS1 expression in HCC tissues (n = 369) and adjacent non-tumor tissues (n = 50). Student’s t test. D RT-qPCR was applied to explore the expression of MRVI1-AS1 in HCC cell lines (Hep3B, HuH7, SK-HEP-1, HepG2, and MHCC-97H) and normal hepatocyte cell line (LO2) (mean ± SD; n = 3). *P < 0.05, two-way ANOVA. E, F The effects of MRVI1-AS1 expression on 5-year overall survival and disease-free survival of HCC patients. Log-rank test