Table 4 Univariate and multivariate analysis of independent risk factors associated to survival after first ipsilateral recurrence

Age (year) at diagnosis

0.392

 < 40

14

2

ref

 ≥40

45

12

1.911 (0.423–8.633)

Breast operation

0.297

 Breast conserving surgery

35

9

ref

 Mastectomy

24

5

0.535 (0.162–1.765)

Axillary operation

0.674

 No

1

0

ref

 SLNB

21

3

5719.640 (0–8.406E165)

 ALND

37

11

10,285.682 (0–1.510E165)

pT

0.094

 1

37

5

ref

 2

22

9

2.563 (0.853–7.701)

pN

0.010

0.140

 0

45

7

ref

ref

 1

11

4

1.297 (0.357–4.714)

0.273 (0.036–2.084)

 2

3

1

1.555 (0.190–12.745)

10.122 (0.399–256.539)

 3

0

2

87.290 (7.554–1023.339)

91.013 (6.209–1334.033)

Pathologic stage

<0.001

<0.001

 I

55

6

ref

ref

 II

4

6

12.378 (3.679–41.646)

11.051 (2.911–41.951)

 III

0

2

199.526 (15.719–2532.702)

113.398 (8.174–1573.235)

ER status

0.045

0.604

 Negative

1

1

ref

ref

 Positive

58

13

0.110 (0.013–0.950)

0.502 (0.037–6.794)

PR status

0.002

0.348

 Negative

9

6

ref

ref

 Positive

50

8

0.176 (0.058–0.532)

0.405 (0.061–2.676)

HG

0.069

 1

17

1

ref

 2

30

7

3.522 (0.432–28.723)

 3

12

6

7.883 (0.934–66.539)

Ki-67

0.063

0.076

 ≤15%

34

4

ref

 > 15

25

10

2.872 (0.895–9.213)

LVI

0.035

0.483

 No

40

4

ref

ref

 Yes

18

10

4.085 (1.264–13.205)

2.744 (0.532–14.141)

 Unknown

1

0

Adjuvant chemotherapy

0.158

 No

30

5

ref

 Yes

29

9

2.209 (0.736–6.633)

Adjuvant radiotherapy

0.325

 No

23

5

ref

 Yes

36

9

1.821 (0.552–6.009)

Adjuvant endocrine therapy

0.761

0.762

 No

2

1

ref

 Yes

57

13

0.730 (0.094–5.635)

Site of first recurrence

0.049

0.476

 Breast

35

5

ref

ref

 Axilla

11

3

1.661 (0.394–7.008)

1.118 (0.500–2.502)

 Chest wall or skin

11

3

1.462 (0.333–6.410)

1.651 (0.647–4.218)

 Two or more

2

3

7.395 (1.742–31.399)

3.327 (1.183–9.358)

Number of recurrence

0.007

1.000

 One

57

11

ref

ref

 Two or more

2

3

6.062 (1.631–22.526)

1.000 (0.057–17.511)

Post-recurrence chemotherapy

0.005

0.190

 No

36

2

ref

ref

 Yes

23

12

8.697 (1.920–39.399)

3.337 (0.551–20.204)

Post-recurrence radiotherapy

0.223

 No

44

12

ref

 Yes

15

2

0.390 (0.086–1.770)

Post-recurrence endocrine therapy

<0.001

<0.001

 No

15

12

ref

ref

 Yes

44

2

0.069 (0.015–0.309)

0.080 (0.016–0.404)

Progression

0.039

<0.001

 No

46

0

ref

ref

 Yes

13

14

160.653 (1.278–20192.383)

143.561 (1.409–1850.352)