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Fig. 1 | World Journal of Surgical Oncology

Fig. 1

From: Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation

Fig. 1

PFKFB3 could be enhanced by hyperglycemia and was correlated with the prognosis of BC patients. A Protein levels of PFKFB3 in benign breast tissues and invasive ductal carcinoma with or without diabetes were detected by IHC. The magnification of the photographs was 200. B The Kaplan–Meier plotter database and C GEO database (GSE61304) were utilized to compare the PFS and OS of breast cancer patients with different PFKFB3 expression levels. D The breast cancer cell lines (BT474 and MCF-7) were cultured in 1640 mediums with different concentrations of glucose (5.5 mM, 15 mM, or 25 mM) and WB was performed to evaluate PFKFB3 expression level. *, P < 0.05; **, P < 0.01; ***, P < 0.001

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World Journal of Surgical Oncology

ISSN: 1477-7819

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