Table 3 Multivariate cox regression analysis of variables associated with recurrence and overall survival
Variables | FU-iCCA cohort (n = 244) | ZSH cohort (n = 259) | ||||
|---|---|---|---|---|---|---|
Overall survival | Overall survival | Recurrence | ||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Vascular invasion (yes versus no) | 1.750 (1.128–2.715) | 0.013 | 1.230 (0.850–1.777) | 0.272 | 1.309 (0.867–1.976) | 0.200 |
LN metastasis (yes versus no) | 2.108 (1.128–3.939) | 0.019 | 4.525 (1.374–14.905) | 0.013 | 1.681 (0.495–5.712) | 0.405 |
Tumor size (> 5 cm versus ≤ 5 cm) | 1.019 (0.658–1.576) | 0.934 | 1.429 (0.997–2.048) | 0.052 | 2.213 (1.473–3.324) |  < 0.001 |
CA199(> 37 U/mL versus ≤ 37 U/mL) | 1.460 (0.913–2.334) | 0.114 | 1.382 (0.971–1.967) | 0.072 | 1.223 (0.821–1.820) | 0.322 |
CEA (> 5 ng/mL versus ≤ 5 ng/mL) | 1.844 (1.190–2.857) | 0.006 | 2.001 (1.402–2.856) |  < 0.001 | 1.201 (0.775–1.861) | 0.414 |
AJCC 8th (III–IV versus I–II) | 1.596 (0.872–2.919) | 0.129 | 0.567 (0.176–1.829) | 0.342 | 0.616 (0.190–1.992) | 0.418 |
CD73 (high versus low) | 1.942 (1.287–2.929) | 0.002 | 3.799 (2.676–5.394) |  < 0.001 | 2.878 (1.959–4.230) |  < 0.001 |