Table 2 Univariate Cox regression analysis of variables associated with recurrence and overall survival
Variables | FU-iCCA cohort (n = 244) | ZSH cohort (n = 259) | ||||
|---|---|---|---|---|---|---|
Overall survival | Overall survival | Recurrence | ||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Sex (male versus female) | 1.002 (0.674–1.490) | 0.991 | 1.044 (0.755–1.443) | 0.794 | 1.424 (0.981–2.066) | 0.063 |
Age (> 60 years versus ≤ 60 years) | 1.024 (0.690–1.521) | 0.905 | 0.938 (0.686–1.282) | 0.689 | 0.787 (0.555–1.116) | 0.179 |
HBsAg (positive versus negative) | 0.657 (0.401–1.074) | 0.094 | 0.797 (0.564–1.126) | 0.198 | 1.010 (0.697–1.462) | 0.959 |
Liver cirrhosis (yes versus no) | 1.259 (0.654–2.425) | 0.491 | 0.859 (0.603–1.223) | 0.398 | 1.166 (0.806–1.689) | 0.415 |
Vascular invasion (yes versus no) | 2.584 (1.727–3.866) |  < 0.001 | 2.114 (1.524–2.933) |  < 0.001 | 2.072 (1.423–3.018) |  < 0.001 |
LN metastasis (yes versus no) | 4.279 (2.829–6.471) |  < 0.001 | 3.215 (2.272–4.547) |  < 0.001 | 1.599 (1.025–2.496) | 0.039 |
Tumor size (> 5 cm versus ≤ 5 cm) | 1.601 (1.062–2.412) | 0.024 | 1.932 (1.396–2.674) |  < 0.001 | 2.493 (1.718–3.619) |  < 0.001 |
CA199 (> 37 U/mL versus ≤ 37 U/mL) | 2.415 (1.574–3.704) |  < 0.001 | 1.894 (1.367–2.624) |  < 0.001 | 1.589 (1.112–2.270) | 0.011 |
CEA (> 5 ng/mL versus ≤ 5 ng/mL) | 2.429 (1.603–3.680) |  < 0.001 | 2.587 (1.861–3.598) |  < 0.001 | 1.711 (1.149–2.548) | 0.008 |
AJCC 8th (III–IV versus I–II) | 3.216 (2.151–4.808) |  < 0.001 | 2.955 (2.105–4.150) |  < 0.001 | 1.567 (1.024–2.398) | 0.039 |
CD73 (high versus low) | 2.262 (1.519–3.368) |  < 0.001 | 4.282 (3.071–5.969) |  < 0.001 | 3.112 (2.160–4.484) |  < 0.001 |