From: The prognostic significance of duodenal wall invasion in pancreatic adenocarcinoma
Characteristics | No. of patients | Progression-free survival | Overall survival | |||
---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |||
Age (y) | ≤ 60 (reference) | 26 | ||||
> 60 | 71 | 2.39 (0.92–6.22) | 0.07 | 2.63 (1.01–6.87) | 0.048* | |
Gender | Female (reference) | 39 | ||||
Male | 58 | 0.77 (0.39–1.55) | 0.46 | 0.76 (0.38–1.51) | 0.43 | |
Race | White (reference) | 70 | ||||
African American | 12 | 4.94 (2.02–12.10) | 0.00* | 5.51 (2.23–13.64) | 0.00* | |
Other | 6 | 2.27 (0.65–7.98) | 0.20 | 2.14 (0.61–7.51) | 0.23 | |
Tumor stage | T1 (reference) | 20 | ||||
T2 | 53 | 0.77 (0.33–1.79) | 0.58 | 0.75 (0.32–1.73) | 0.49 | |
T3 | 24 | 1.16 (0.45–2.94) | 0.76 | 1.21 (0.47–3.07) | 0.69 | |
Tumor grading | G1 | 5 | ||||
G2 | 67 | 0.66 (0.19–2.27) | 0.51 | 0.67 (0.19–2.34) | 0.54 | |
G3 | 25 | 1.22 (0.33–4.48) | 0.76 | 1.16 (0.32–4.24) | 0.81 | |
Lymph node involved | No (reference) | 26 | ||||
Yes | 71 | 1.11 (0.51–2.41) | 0.78 | 1.09 (0.50–2.35) | 0.84 | |
Duodenal invasion | Negative (reference) | 44 | ||||
Positive | 53 | 0.47 (0.23–0.95) | 0.03* | 0.48 (0.23–0.97) | 0.04* | |
Lymphovascular invasion | Negative (reference) | 27 | ||||
Positive | 70 | 1.07 (0.49–2.32) | 0.86 | 1.06 (0.48–2.28) | 0.89 | |
Perineural invasion | Negative (reference) | 15 | ||||
Positive | 82 | 0.65 (0.26–1.59) | 0.34 | 0.62 (0.25–1.53) | 0.30 | |
Ampullary invasion | Negative (reference) | 63 | ||||
Positive | 34 | 0.96 (0.45–2.03) | 0.91 | 0.91 (0.43–1.93) | 0.82 | |
CBD invasion | Negative (reference) | 79 | ||||
Positive | 18 | 0.94 (0.36–2.45) | 0.89 | 0.85(0.33–2.21) | 0.74 | |
Margin status | Negative (reference) | 68 | ||||
Positive | 29 | 1.69 (0.81–3.57) | 0.16 | 1.59 (0.76–3.33) | 0.21 |