Fig. 7

Trial sequential analysis of trials reporting HR between RA and GA on postoperative RFS and OS; green line (Z = 1.96), dashed red line (monitoring boundary, UB), blue line (cumulative z curve), red line (sample size); the cumulative z curve was constructed using a random-effects model. A The AIS graph for RFS. B The APIS graph for RFS. C The AIS graph for OS. D The APIS graph for OS; the APIS graph showed that for an RRR of 38%, alpha 5%, and a power of 80%, the number of optimal patients for RFS is 4776 and for OS is 3411, z curve (blue line) reached the information size (red line) for both RFS and OS which provides firm evidence of effect