Table 1 Demographics accordingly ACCI groups

Clinical preoperative characteristics

  Number of patients

211

117

94

  Age (y), median (IQR)

65 (60–70)

61 (56.5–67)

69.5 (64–73)

< 0.001^c

  Gender: male, n (%)

181 (85.8)

100 (85.5)

81 (86.2)

0.885^a

  BMI (kg/m²), median (IQR)

25.4 (23.8–27.6)

25.4 (23.7–27.5)

25.4 (23.8–27.7)

0.850^b

  Hemoglobin (g/dl), median (IQR)

12.1 (11–13.4)

12.3 (11.2–13.7)

11.6 (10.6–12.9)

0.015^b

  e-GFR before cystectomy (ml/min/1.73 m²), median (IQR)

79 (52–92)

81 (63.5–96.7)

67.9 (45.0–87.0)

< 0.001^c

  Hydronephrosis, n (%)

62 (29.4)

37 (31.6)

25 (26.6)

0.451^a

  Smoking, n (%)

168 (79.6)

99 (84.6)

69 (73.4)

0.044^a

  Prior pelvic or abdominal surgery, n (%)

53 (25.1)

23 (19.7)

30 (31.9)

0.041^a

  Intravesical treatment, n (%)

34 (16.2)

18 (15.2)

16 (17.0)

0.899^a

  Prior systemic chemotherapy, n (%)

38 (18)

21 (17.9)

17 (18.1)

0.980^a

Surgical characteristics

  Operative time (min), median (IQR)

420 (370–480)

420 (390–497.5)

420 (360–480)

0.031^c

  Intraoperative blood loss (ml), median (IQR)

1100 (700–1725)

1100 (800–1675)

1100 (650–1925)

0.840^c

  Length of stay (d), median (IQR)

12 (11–15)

12 (11–14)

12 (11–15)

0.559^c

  Mortality, n (%)

126 (59.7)

64 (54.7)

62 (66)

0.098^c

Clinical stage

0.436^c

  cT1, n (%)

13 (6.2)

5 (4.3)

8 (8.5)

  cT2, n (%)

106 (50.2)

59 (50.4)

47 (50)

  cT3, n (%)

65 (30.8)

36 (30.8)

29 (30.8)

  cT4, n (%)

27 (12.8)

17 (14.5)

10 (10.6)

Cystectomy characteristics

  pT stage

0.052^c

   pT0, n (%)

12 (5.7)

7 (6)

5 (5.3)

   pTa, n (%)

6 (2.9)

2 (1.7)

4 (4.3)

   pT1, n (%)

18 (8.5)

8 (6.8)

10 (10.6)

   pT2, n (%)

54 (25.6)

35 (29.9)

19 (20.2)

   pT3, n (%)

69 (32.7)

45 (38.5)

24 (25.5)

   pT4, n (%)

50 (23.7)

20 (17.1)

30 (31.9)

   CIS, n (%)

2 (0.9)

0

2 (0.9)

 pN stage

0.530^a

   pN0, n (%)

133 (63)

71 (60.7)

62 (65.9)

   pN+, n (%)

78 (37)

46 (39.3)

32 (34.1)

Number of lymph nodes resected, median (IQR)

19 (14-27)

19 (15-28)

18.5 (13-25.5)

0.234^c

Variant histology, n (%)

41 (19.4)

22 (18.8)

19 (20.2)

0.797^a

Lymphovascular invasion, n (%)

90 (42.7)

51 (43.6)

39 (41.5)

0.759^a

Presence of CIS, n (%)

61 (26.8)

28 (23.9)

29 (30.9)

0.261^a

Positive surgical margin, n (%)

13 (6.2)

10 (8.5)

3 (3.2)

0.104^a

Urinary diversion type

0.023^a

Continent (Studer), n (%)

10 (4.7)

9 (7.7)

1 (1.1)

Incontinent (ileal loop), n (%)

201 (95.3)

108 (92.3)

93 (98.9)