Fig. 4

The immune landscape of the PI3K pathway mutation and wild groups in the TCGA-HNSC cohort. A Distribution of 26 immune and stromal cell infiltration calculated by xCell in the PI3K pathway mutation and wild groups. B, C Boxplots represent different expression levels of 20 co-stimulatory molecules (B) and 12 co-inhibitory molecules (C) between the two groups. D–G Boxplots of neoantigen (D), SNV neoantigens (E), nonsilent mutation rate (F), and TCR Shannon (G) for patients in the two groups. WT, wild type; Mut, mutant type. *P < 0.05; **P < 0.01