Fig. 2

Genomic alteration landscape. A Genomic alteration landscape of the PI3K pathway mutation and wild groups. TMB, patient subgroups, the relative contribution of four mutational signatures, selected top 15 mutated genes, broad-level CNAs (> 33%), and selected genes located within chromosomes 7p11.2, 3p24.1, and 9p21.3 are shown from the top to the bottom panels. The relative proportions for the frequencies of each alteration between the PI3K pathway mutation and wild groups are presented in the right bar charts. B–D The PI3K pathway mutation group is significantly associated with higher TMB in the MSKCC-2019 (B), TCGA-HNSC (C), and MD-Anderson (D) cohorts. E–H Differences in copy number amplification loads at chromosomal arm (E) and focal (G) levels, as well as differences in copy number deletion loads at chromosomal arm (F) and focal (H) levels between the two groups in the TCGA-HNSC cohort. WT, wild type; Mut, mutant type