Fig. 1

Landscapes and clinical prognostic value of PI3K pathway mutation in HNSC. A, B Oncoplot depicts the mutated PI3K pathway genes of HNSC in the MSKCC-2019 (A) and TCGA-HNSC (B) cohorts. The left panel shows the mutation rate, and PI3K pathway genes are ordered by their mutation frequencies. The right panel presents different mutation types. C, D Multivariate Cox regression analysis of PI3K pathway mutation phenotype. E, F Kaplan-Meier survival analysis of the PI3K pathway mutation and wild groups in the MSKCC-2019 (n = 129) and TCGA-HNSC (n = 501) cohorts. WT, wild type; Mut, mutant type