Table 5 Univariate and multivariate analyses incorporating the NCS

Sex

0.728

 Female

1

 Male

1.052 (0.790–1.403)

Age

<0.001

0.024

 <65years

1

1

 ≥65years

1.963 (1.516–2.541)

1.375 (1.042–1.813)

Tumor size

<0.001

 <5cm

1

 ≥5cm

1.666 (1.294–2.147)

Differentiation

0.008

 Moderate/well

1

 Poor

1.409 (1.094–1.814)

Borrmann type

<0.001

 I–II

1

 III–IV

1.614 (1.253–2.079)

Tumor depth

<0.001

0.018

 T1

1

1

 T2

4.305 (1.215–15.258)

0.024

1.332 (0.221–8.038)

0.755

 T3

11.662 (3.710–36.658)

<0.001

1.240 (0.181–8.488)

0.827

 T4

41.409 (13.073–131.166)

<0.001

2.202 (0.313–15.492)

0.428

Lymph node

<0.001

 N0

1

 N1

5.937 (3.398–10.375)

<0.001

 N2

10.133 (5.736–17.902)

<0.001

 N3

15.816 (8.540–29.291)

<0.001

Distant metastasis

<0.001

 M0

1

 M1

4.458 (3.022–6.577)

pTNM stage

<0.001

<0.001

 I

1

1

 II

6.519 (2.623–16.200)

<0.001

2.396 (0.446–12.859)

0.308

 III

25.415 (10.389–62.172)

<0.001

5.445 (0.889–33.357)

0.067

 IV

51.590 (19.885–133.844)

<0.001

10.274 (1.677–62.953)

0.012

CEA

<0.001

 ≤5ng/ml

1

 >5ng/ml

2.098 (1.626–2.706)

PLR

<0.001

 ≤127.8

1

 >127.8

1.979 (1.518–2.580)

LMR

<0.001

 ≤4.93

1

 >4.93

0.365 (0.276–0.484)

NCS

<0.001

<0.001

 0

1

1

 1

5.874 (4.048–8.524)

<0.001

3.172 (2.120–4.745)

<0.001

 2

8.710 (5.795–13.093)

<0.001

3.052 (1.928–4.832)

<0.001