Table 3 Univariate and multivariate analyses of variables associated with OS

Sex

0.728

 Female

1

 Male

1.052 (0.790–1.403)

Age

<0.001

0.038

 <65 years

1

1

 ≥65 years

1.963 (1.516–2.541)

1.342 (1.017–1.771)

Tumor size

<0.001

 <5cm

1

 ≥5cm

1.666 (1.294–2.147)

Differentiation

0.008

 Moderate/well

1

 Poor

1.409 (1.094–1.814)

Borrmann type

<0.001

 I–II

1

 III–IV

1.614 (1.253–2.079)

Tumor depth

<0.001

0.009

 T1

1

1

 T2

4.305 (1.215–15.258)

0.024

1.218 (0.202–7.341)

0.829

 T3

11.662 (3.710–36.658)

<0.001

1.200 (0.176–8.203)

0.852

 T4

41.409 (13.073–131.166)

<0.001

2.228 (0.317–15.649)

0.421

Lymph node

<0.001

 N0

1

 N1

5.937 (3.398–10.375)

<0.001

 N2

10.133 (5.736–17.902)

<0.001

 N3

15.816 (8.540–29.291)

<0.001

Distant metastasis

<0.001

 M0

1

 M1

4.458 (3.022–6.577)

pTNM stage

<0.001

<0.001

 I

1

 II

6.519 (2.623–16.200)

<0.001

2.673 (0.501–14.263)

0.250

 III

25.415 (10.389–62.172)

<0.001

5.570 (0.915–33.897)

0.062

 IV

51.590 (19.885–133.844)

<0.001

11.700 (1.921–71.263)

0.008

CEA

<0.001

 ≤5ng/ml

1

 >5ng/ml

2.098 (1.626–2.706)

CA19-9

<0.001

0.016

 ≤37U/ml

1

1

 >37U/ml

2.937 (2.256–3.823)

1.442 (1.072–1.939)

NLR

<0.001

0.001

 ≤2.46

1

1

 >2.46

4.468 (3.303–6.045)

1.772 (1.245–2.522)

PLR

<0.001

 ≤127.8

1

 >127.8

1.979 (1.518–2.580)

LMR

<0.001

 ≤4.93

1

 >4.93

0.365 (0.276–0.484)