Antiviral therapy inhibited HBV-reactivation and improved long-term outcomes in patients who underwent radiofrequency ablation for HBV-related hepatocellular carcinoma

Table 4 Patterns of tumor recurrence

Parameter	AVT group (n = 215)	Non-AVT group (n = 215)	P
Type of recurrence	145	185	0.992
Intrahepatic^a (n = 305)	134	171
Extrahepatic^b (n = 11)	5	6
Intrahepatic plus extrahepatic^c (n = 14)	6	8
Site of intrahepatic recurrence^d	134	171	0.312
Local (n = 21)	13	8	0.263
Adjacent segment (n = 80)	37	43	0.457
Distant segment (n = 189)	78	111	0.001
Multi-segments (n = 15)	6	9	0.430
Time to recurrence, months	145	185
≤ 24 (n = 230)	106	124	0.082
> 24 (n = 100)	39	61	0.012

^aIncluded intrahepatic recurrence only
^bExtrahepatic recurrence only
^cIntra-plus extrahepatic recurrence
^dLocal recurrence is defined as any recurrence at the ablation zone after PRFA within 1 cm, irrespective of additional recurrence in other parts of the liver; recurrence in the adjacent segment is defined as any recurrence in the adjacent segment or in the same segment 1 cm away from ablation zone; recurrence in distant segment refers to any recurrence that was not in the adjacent segment or in the contralateral hemiliver; recurrence in multi-segments indicates multiple recurrences involving more than two hepatic segments

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