Comparison of the prognostic value of stromal tumor-infiltrating lymphocytes and CD3 + T cells between schistosomal and non-schistosomal colorectal cancer

Table 2 The association between schistosomiasis and clinicopathological features and infiltrating immune cells

Characteristics	NSCRC (N = 188*)	SCRC (N = 126*)	p
Age (< 60 years)			< 0.0001
< 60	68	5
≥ 60	120	121
Gender			0.348
Male	79	46
Female	109	80
Tumor site			0.530
Rectum	47	36
Left colon	59	43
Right colon	82	47
Tumor size			0.908
< 5 cm	95	62
≥ 5 cm	93	64
Tumor differentiation			0.500
Well/moderately diff	146	93
Poorly diff	42	33
Lymphangio			0.811
Negative	119	82
Positive	69	44
Nervous invasion			1.000
Negative	171	115
Positive	17	11
Tumor deposit			1.000
≤ 2	165	110
> 2	23	16
Colonic perforation			1.000
No	181	121
Yes	7	5
Ulceration			0.559
No	113	71
Yes	75	55
Pathological T stage			0.689
T1-2	48	29
T3-4	140	97
LNM			0.907
No	108	74
Yes	80	52
TNM stage			0.730
I + II	99	69
III + IV	89	57
Tumor budding			0.906
< 5 cells	75	49
≥ 5 cells	113	77
Histological type			0.866
Adenocarcinoma	164	109
Mucinous/SRCC	24	17
sTILs			0.287
Poor	67	53
Rich	121	73
iTILs			0.164
Poor	185	120
Rich	3	6
CD3			0.219
Poor	123	91
Rich	65	35
CD20			0.728
Poor	104	73
Rich	84	53

Abbreviations: NSCRC Non-schistosomal colorectal cancer, SCRC Schistosomal colorectal cancer, N Number, LNM Lymph node metastasis, SRCC Signet ring cell carcinoma, sTILs stromal tumor-infiltrating lymphocytes, iTILs intratumoral-infiltrating lymphocytes. The association between schistosomiasis and clinicopathological characteristics was evaluated by using the chi-square and Fisher’s exact tests
^*Although 349 CRC patients were enrolled in the cohort, some sample tissues were unavailable for the immunohistochemical assay, such as those with high-fat content. Finally, there were 314 cases could be used for the following analysis of CD3 and CD20

ISSN: 1477-7819