Fig. 4

Kaplan–Meier curves of overall survival (OS) revealing prognostic significance of TILs in CRC patients with schistosomiasis (N = 126). There was significantly association between OS and sTILs (≥ 2% was defined as sTILs-rich group, otherwise as sTILs-poor group) (P = 0.0119) A, higher CD3-positive expression B (P = 0.0097), and higher CD20-positive expression (P = 0.0412) C was associated with better prognosis in CRC patients with schistosomiasis. Note: Although 349 CRC patients were enrolled in the cohort and used for HE staining of TILs, but some sample tissues were unavailable for the immunohistochemical assay, such as those with high-fat content. Finally, there were 314 cases could be used for the following analysis of CD3 and CD20. Among these 314 cases, the number of patients without schistosomiasis was 126