Fig. 3

Abnormal expression of METTL3 affects the growth of CSCC tumors. A Typical CSCC tumors from mice after subcutaneous injection of C33A cells with overexpression or knockdown of METTL3 (n=5). B, C The volume and weight of CSCC subcutaneous tumors in mice after different treatments (n=5). D HE staining of tumor tissues (n=5). E, F METTL3 expression in CSCC tumor tissue was determined by IHC staining and qRT-PCR, respectively (n=5). *p<0.05, **p<0.01, ***p<0.001